Calorie restriction in humans: an update
Calorie restriction (CR), a nutritional intervention of reduced energy intake but with adequate
nutrition, has been shown to extend healthspan and lifespan in rodent and primate models …
nutrition, has been shown to extend healthspan and lifespan in rodent and primate models …
Caloric restriction
JR Speakman, SE Mitchell - Molecular aspects of medicine, 2011 - Elsevier
Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …
length and quality of life for over 500years. Experimental work confirming the success of this …
[PDF][PDF] Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes
Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether
these effects are due solely to weight loss. We conducted the first supervised controlled …
these effects are due solely to weight loss. We conducted the first supervised controlled …
[PDF][PDF] Metabolic slowing and reduced oxidative damage with sustained caloric restriction support the rate of living and oxidative damage theories of aging
Calorie restriction (CR) is a dietary intervention with potential benefits for healthspan
improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we …
improvement and lifespan extension. In 53 (34 CR and 19 control) non-obese adults, we …
American Association of Clinical Endocrinologists and American College of Endocrinology comprehensive clinical practice guidelines for medical care of patients with …
WT Garvey, JI Mechanick, EM Brett, AJ Garber… - Endocrine Practice, 2016 - Elsevier
Objective Development of these guidelines is mandated by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and the American College of …
Clinical Endocrinologists (AACE) Board of Directors and the American College of …
A randomized controlled trial to isolate the effects of fasting and energy restriction on weight loss and metabolic health in lean adults
I Templeman, HA Smith, E Chowdhury… - Science translational …, 2021 - science.org
Intermittent fasting may impart metabolic benefits independent of energy balance by
initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour …
initiating fasting-mediated mechanisms. This randomized controlled trial examined 24-hour …
[HTML][HTML] β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity
JM Valentine, M Ahmadian, O Keinan… - The Journal of …, 2022 - Am Soc Clin Investig
The dysregulation of energy homeostasis in obesity involves multihormone resistance.
Although leptin and insulin resistance have been well characterized, catecholamine …
Although leptin and insulin resistance have been well characterized, catecholamine …
[HTML][HTML] Induction of adipose tissue browning as a strategy to combat obesity
A Kuryłowicz, M Puzianowska-Kuźnicka - International Journal of …, 2020 - mdpi.com
The ongoing obesity pandemic generates a constant need to develop new therapeutic
strategies to restore the energy balance. Therefore, the concept of activating brown adipose …
strategies to restore the energy balance. Therefore, the concept of activating brown adipose …
Energy availability and the female athlete triad in elite endurance athletes
The female athlete triad (T riad), links low energy availability (EA), with menstrual
dysfunction (MD), and impaired bone health. The aims of this study were to examine …
dysfunction (MD), and impaired bone health. The aims of this study were to examine …
Cellular bioenergetics as a target for obesity therapy
Obesity develops when energy intake exceeds energy expenditure. Although most current
obesity therapies are focused on reducing calorific intake, recent data suggest that …
obesity therapies are focused on reducing calorific intake, recent data suggest that …