Preclinical studies of COVID-19 mRNA vaccine BNT162b2, developed by Pfizer and
BioNTech, showed reversible hepatic effects in animals that received the BNT162b2 …

Prolonged detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
RNA and recurrence of PCR-positive tests have been widely reported in patients after …

The major advantage of mRNA vaccines over more conventional approaches is their
potential for rapid development and large-scale deployment in pandemic situations. In the …

A rapid induction of antiviral genes is critical for eliminating viruses, which requires activated
transcription factors and opened chromatins to initiate transcription. However, it remains …

Highlights•Host transposable elements (TEs) are induced by many RNA and DNA virus
infections.•TE induction by influenza virus involves post-translational changes to host …

SARS-CoV-2 promotes an imbalanced host response that underlies the development and
severity of COVID-19. Infections with viruses are known to modulate transposable elements …

Many RNA-based drugs, both vaccines and non-vaccines, are under development or even
approved. They include coding mRNAs and non-coding (nc) RNAs among them antisense …

The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
caused a worldwide pandemic (COVID-19) after emerging in Wuhan, China. Here we …

Therapeutic applications of synthetic mRNA were proposed more than 30 years ago, and
are currently the basis of one of the vaccine platforms used at a massive scale as part of the …

Abstract Long INterspersed Element 1 (LINE-1 or L1) acts as a major remodeling force in
genome regulation and evolution. Accumulating evidence shows that virus infection impacts …