Liver fibrosis is a reversible wound-healing process aimed at maintaining organ integrity,
and presents as the critical pre-stage of liver cirrhosis, which will eventually progress to …

Fibrosis is the extensive deposition of fibrous connective tissue, and it is characterized by
the accumulation of collagen and other extracellular matrix (ECM) components. Fibrosis is …

Liver fibrosis is a dynamic wound-healing process characterized by the net accumulation of
extracellular matrix. There is no efficient antifibrotic therapy other than liver transplantation to …

Nonalcoholic fatty liver disease (NAFLD) is the dominant cause of liver disease worldwide.
Nonalcoholic steatohepatitis (NASH), a more aggressive presentation of NAFLD, is …

Intestinal fibrosis is an important complication of inflammatory bowel disease (IBD). In the
course of the development of fibrosis, certain parts of the intestine become narrowed …

Nonalcoholic fatty liver disease (NAFLD) can progress from simple steatosis (ie,
nonalcoholic fatty liver [NAFL]) to nonalcoholic steatohepatitis (NASH), cirrhosis, and cancer …

Chronic liver injury of different etiologies may result in hepatic fibrosis, a scar formation
process consisting in altered deposition of extracellular matrix. Progression of fibrosis can …

The interleukin (IL)-6/IL-12 family cytokines have pleiotropic functions and play critical roles
in multiple immune responses. This cytokine family has very unique characteristics in that …

Recent scientific findings support the notion that fibrosis is driven by tissue-specific cellular
and molecular mechanisms. Analysis of seemingly equivalent mesenchymal stromal cell …

The role of the immune system in anti-tumor immunity cannot be overstated, as it holds the
potential to promote tumor eradication or prevent tumor cell escape. Cytokines are critical to …