Microglia are brain resident macrophages originated from primitive progenitor cells in the
yolk sac. Microglia can be activated within hours and recruited to the lesion site …

The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs)
together with neurons and glial cells, including microglia, forms the neurovascular unit …

Inflammatory activation of microglia is a hallmark of several disorders of the central nervous
system. In addition to protecting the brain against inflammatory insults, microglia are …

Aging is an inevitable biological process characterized by a progressive decline in
physiological function and increased susceptibility to disease. The detrimental effects of …

The emerging roles of microglia are currently being investigated in the healthy and diseased
brain with a growing interest in their diverse functions. In recent years, it has been …

Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and
spinal cord injury (SCI), are important causes of death and long-term disability worldwide …

Biological differences between males and females are found at multiple levels. However,
females have too often been under-represented in behavioral neuroscience research, which …

Rett syndrome (RTT) is an X-linked, neurodevelopmental disorder caused primarily by
mutations in the methyl-CpG-binding protein 2 (MECP2) gene, which encodes a …

The discovery of miRNAs as important regulatory agents for gene expression has expanded
the therapeutic opportunities for oligonucleotides. In contrast to siRNA, miRNA-targeted …

Sporadic Alzheimer's disease (AD) is the most prevalent form of dementia, but no clear
disease‐initiating mechanism is known. Aβ deposits and neuronal tangles composed of …