The surprising discovery that the diatomic gas nitric oxide (NO) is generated by mammalian
cells and serves to regulate a multitude of physiological processes has continued to …

Nanoparticles (NPs) are increasingly used in a wide variety of applications and products;
however, NPs may affect stress response pathways and interact with proteins in biological …

Background: Endothelial cells depend on glycolysis for much of their energy production.
Impaired endothelial glycolysis has been associated with various vascular pathobiologies …

Formation of NO by endothelial NOS (eNOS) is a central process in the homeostatic
regulation of vascular functions including blood pressure regulation, and fluid shear stress …

Nitric oxide (NO) plays several key roles in the functionality of an organism, and it is usually
released in numerous organs and tissues. There are mainly three isoforms of the enzyme …

Systemic chronic microinflammation and altered cytokine signaling, with adjunct
cardiovascular disease (CVD), endothelial maladaptation and dysfunction is common in …

Cardiovascular aging presents a formidable challenge, as the aging process can lead to
reduced cardiac function and heightened susceptibility to cardiovascular diseases …

Aims Damage of the blood–brain barrier (BBB) is a hallmark of brain injury during the early
stages of ischemic stroke. The subsequent endothelial hyperpermeability drives the initial …

Aims The prevalence of left ventricular (LV) diastolic and vascular dysfunction increases with
age, eventually leading to heart failure with preserved ejection fraction (HFpEF). A …

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating disease
characterized by severe and persistent fatigue. Along with clinical studies showing …