Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: Perspectives for immunotherapy of SCLC
X Niu, L Chen, Y Li, Z Hu, F He - Seminars in Cancer Biology, 2022 - Elsevier
Small cell lung cancer (SCLC) is an aggressive form of lung cancer characterized by dismal
prognosis. Although SCLC may initially respond well to platinum-based chemotherapy, it …
prognosis. Although SCLC may initially respond well to platinum-based chemotherapy, it …
A review on CRISPR/Cas: a versatile tool for cancer screening, diagnosis, and clinic treatment
X Yang, B Zhang - Functional & Integrative Genomics, 2023 - Springer
Cancer is one of the leading causes of death worldwide and it has the trend of increase
incidence. However, in the past decades, as quickly developed new technologies and …
incidence. However, in the past decades, as quickly developed new technologies and …
KDM6A epigenetically regulates subtype plasticity in small cell lung cancer
Small cell lung cancer (SCLC) exists broadly in four molecular subtypes: ASCL1,
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …
NEUROD1, POU2F3 and Inflammatory. Initially, SCLC subtypes were thought to be mutually …
Inhibition of LSD1 with bomedemstat sensitizes small cell lung cancer to immune checkpoint blockade and T-cell killing
JB Hiatt, H Sandborg, SM Garrison, HU Arnold… - Clinical Cancer …, 2022 - AACR
Purpose: The addition of immune checkpoint blockade (ICB) to platinum/etoposide
chemotherapy changed the standard of care for small cell lung cancer (SCLC) treatment …
chemotherapy changed the standard of care for small cell lung cancer (SCLC) treatment …
[HTML][HTML] Targeting the Notch signaling pathway and the Notch ligand, DLL3, in small cell lung cancer
H Zhang, Y Yang, X Li, X Yuan, Q Chu - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Small cell lung cancer (SCLC) is a highly aggressive and poorly differentiated cancer with
high-grade neuroendocrine (NE) features, accounting for approximately 15% of all lung …
high-grade neuroendocrine (NE) features, accounting for approximately 15% of all lung …
Stimulation of cGAS-STING pathway as a challenge in the treatment of small cell lung cancer: a feasible strategy?
Lung cancer has a significant incidence among the population and, unfortunately, has an
unfavourable prognosis in most cases. The World Health Organization (WHO) classifies lung …
unfavourable prognosis in most cases. The World Health Organization (WHO) classifies lung …
Molecular phenotyping of small cell lung cancer using targeted cfDNA profiling of transcriptional regulatory regions
JB Hiatt, AL Doebley, HU Arnold, M Adil… - Science …, 2024 - science.org
We report an approach for cancer phenotyping based on targeted sequencing of cell-free
DNA (cfDNA) for small cell lung cancer (SCLC). In SCLC, differential activation of …
DNA (cfDNA) for small cell lung cancer (SCLC). In SCLC, differential activation of …
Single-cell and spatial proteo-transcriptomic profiling reveals immune infiltration heterogeneity associated with neuroendocrine features in small cell lung cancer
Y Jin, Y Wu, A Reuben, L Zhu, CM Gay, Q Wu, X Zhou… - Cell Discovery, 2024 - nature.com
Small cell lung cancer (SCLC) is an aggressive pulmonary neuroendocrine malignancy
featured by cold tumor immune microenvironment (TIME), limited benefit from …
featured by cold tumor immune microenvironment (TIME), limited benefit from …
[HTML][HTML] Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1
Despite small cell lung cancers (SCLCs) having a high mutational burden, programmed
death-ligand 1 (PD-L1) immunotherapy only modestly increases survival. A subset of SCLCs …
death-ligand 1 (PD-L1) immunotherapy only modestly increases survival. A subset of SCLCs …
Genetically-engineered mouse models of small cell lung cancer: the next generation
Small cell lung cancer (SCLC) remains the most fatal form of lung cancer, with patients in
dire need of new and effective therapeutic approaches. Modeling SCLC in an …
dire need of new and effective therapeutic approaches. Modeling SCLC in an …