Approaches to test the neurotoxicity of environmental contaminants in the zebrafish model: From behavior to molecular mechanisms

JA Fitzgerald, S Könemann… - Environmental …, 2021 - Wiley Online Library
The occurrence of neuroactive chemicals in the aquatic environment is on the rise and
poses a potential threat to aquatic biota of currently unpredictable outcome. In particular …

Zebrafish models for skeletal and extraskeletal osteogenesis imperfecta features: unveiling pathophysiology and paving the way for drug discovery

C Masiero, C Aresi, A Forlino, F Tonelli - Calcified Tissue International, 2024 - Springer
In the last decades, the easy genetic manipulation, the external fertilization, the high
percentage of homology with human genes and the reduced husbandry costs compared to …

[HTML][HTML] Adverse effects of bifenthrin exposure on neurobehavior and neurodevelopment in a zebrafish embryo/larvae model

K Eghan, S Lee, D Yoo, CH Kim, WK Kim - Chemosphere, 2023 - Elsevier
Bifenthrin, a third-generation synthetic pyrethroid, is widely used as an agricultural
insecticide. However, it can flow into surface and groundwater, leading to adverse …

Electrical impedance myography detects age-related skeletal muscle atrophy in adult zebrafish

SB Rutkove, S Callegari, H Concepcion, T Mourey… - Scientific Reports, 2023 - nature.com
Age-related deficits in skeletal muscle function, termed sarcopenia, are due to loss of muscle
mass and changes in the intrinsic mechanisms underlying contraction. Sarcopenia is …

Isoquinoline Alkaloids from Coptis chinensis Franch: Focus on Coptisine as a Potential Therapeutic Candidate against Gastric Cancer Cells

S Nakonieczna, A Grabarska, K Gawel… - International Journal of …, 2022 - mdpi.com
Gastric cancer (GC) has high incidence rates and constitutes a common cause of cancer
mortality. Despite advances in treatment, GC remains a challenge in cancer therapy which is …

Cerium oxide nanoparticles as antioxidant or pro-oxidant agents

D Dutta, R Mukherjee, S Ghosh, M Patra… - ACS Applied Nano …, 2022 - ACS Publications
This study was initiated to resolve the ambiguity of contradictory pro-oxidant (toxic) and
antioxidant (protective) effects of cerium oxide nanoparticles (CeONPs) taking zebrafish as a …

Significance of Astragaloside IV from the Roots of Astragalus mongholicus as an Acetylcholinesterase Inhibitor—From the Computational and Biomimetic Analyses to …

K Stępnik, W Kukula-Koch, W Plazinski… - International Journal of …, 2023 - mdpi.com
The main aim of the study was to assess the acetylcholinesterase-inhibitory potential of
triterpenoid saponins (astragalosides) found in the roots of Astragalus mongholicus. For this …

Ephedrine and cocaine cause developmental neurotoxicity and abnormal behavior in zebrafish

DD Ma, WJ Shi, SY Li, JG Zhang, ZJ Lu, XB Long… - Aquatic Toxicology, 2023 - Elsevier
Ephedrine (EPH) and cocaine (COC) are illegal stimulant drugs, and have been frequently
detected in aquatic environments. EPH and COC have negative effects on the nervous …

Genetic compensation triggered by actin mutation prevents the muscle damage caused by loss of actin protein

TE Sztal, EA McKaige, C Williams, AA Ruparelia… - PLoS …, 2018 - journals.plos.org
The lack of a mutant phenotype in homozygous mutant individuals' due to compensatory
gene expression triggered upstream of protein function has been identified as genetic …

Phenotypic Characterization of Larval Zebrafish (Danio rerio) with Partial Knockdown of the cacna1a Gene

K Gawel, WA Turski, W van der Ent, BJ Mathai… - Molecular …, 2020 - Springer
The CACNA1A gene encodes the pore-forming α1 subunit of voltage-gated P/Q type Ca 2+
channels (Ca v 2.1). Mutations in this gene, among others, have been described in patients …