Opioid use disorder
J Strang, ND Volkow, L Degenhardt… - Nature reviews Disease …, 2020 - nature.com
Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …
Sex differences in neural mechanisms mediating reward and addiction
JB Becker, E Chartoff - Neuropsychopharmacology, 2019 - nature.com
There is increasing evidence in humans and laboratory animals for biologically based sex
differences in every phase of drug addiction: acute reinforcing effects, transition from …
differences in every phase of drug addiction: acute reinforcing effects, transition from …
Understanding the broad influence of sex hormones and sex differences in the brain
BS McEwen, TA Milner - Journal of neuroscience research, 2017 - Wiley Online Library
Sex hormones act throughout the entire brain of both males and females via both genomic
and nongenomic receptors. Sex hormones can act through many cellular and molecular …
and nongenomic receptors. Sex hormones can act through many cellular and molecular …
Sex differences in dopamine release regulation in the striatum
The mesolimbic dopamine system—which originates in the ventral tegmental area and
projects to the striatum—has been shown to be involved in the expression of sex-specific …
projects to the striatum—has been shown to be involved in the expression of sex-specific …
[HTML][HTML] Estrogen as a key regulator of energy homeostasis and metabolic health
Over the last two decades, it has become evident that estrogens preserve the integrity of
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …
energy homeostasis at central and peripheral levels. Estrogen deficiency, such as that …
Sex differences in fear extinction
Despite the exponential increase in fear research during the last years, few studies have
included female subjects in their design. The need to include females arises from the …
included female subjects in their design. The need to include females arises from the …
Hypothalamic oestrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure
JE van Veen, LG Kammel, PC Bunda, M Shum… - Nature …, 2020 - nature.com
Oestrogen receptor alpha (ERα) signalling in the ventromedial hypothalamus (VMH)
contributes to energy homeostasis by modulating physical activity and thermogenesis …
contributes to energy homeostasis by modulating physical activity and thermogenesis …
Kappa opioid receptors drive a tonic aversive component of chronic pain
SS Liu, S Pickens, NE Burma… - Journal of …, 2019 - Soc Neuroscience
Pain is a multidimensional experience and negative affect, or how much the pain is
“bothersome”, significantly impacts the sufferers' quality of life. It is well established that the κ …
“bothersome”, significantly impacts the sufferers' quality of life. It is well established that the κ …
[HTML][HTML] Endogenous opioid systems alterations in pain and opioid use disorder
JA Higginbotham, T Markovic, N Massaly… - Frontiers in systems …, 2022 - frontiersin.org
Decades of research advances have established a central role for endogenous opioid
systems in regulating reward processing, mood, motivation, learning and memory …
systems in regulating reward processing, mood, motivation, learning and memory …
Sex-related differences in pharmacokinetics and pharmacodynamics of frequently prescribed drugs: a review of the literature
A Farkouh, T Riedl, R Gottardi, M Czejka… - Advances in …, 2020 - Springer
While there is considerable evidence about sex-related differences between men and
women in drug metabolism, efficacy and safety of frequently prescribed drugs such as …
women in drug metabolism, efficacy and safety of frequently prescribed drugs such as …