Over the past several decades, numerous studies have greatly expanded our knowledge
about how microtubule organization and dynamics are controlled in cultured cells in vitro …

Desmosomes are adhesive intercellular junctions that mechanically integrate adjacent cells
by coupling adhesive interactions mediated by desmosomal cadherins to the intermediate …

The plakin family consists of giant proteins involved in the cross-linking and organization of
the cytoskeleton and adhesion complexes. They further modulate several fundamental …

Cadherin-based adherens junctions (AJs) and desmosomes are crucial to couple
intercellular adhesion to the actin or intermediate filament cytoskeletons, respectively. As …

The development of adhesive connections between cells was critical for the evolution of
multicellularity and for organizing cells into complex organs with discrete compartments …

Desmosomes are intercellular junctions that mediate cell–cell adhesion and anchor the
intermediate filament network to the plasma membrane, providing mechanical resilience to …

Cell–cell adhesions are necessary for structural integrity and barrier formation of the
epidermis. Here, we discuss insights from genetic and cell biological studies into the roles of …

Inverse comorbidity is a lower-than-expected probability of disease occuring in individuals
who have been diagnosed with other medical conditions. Emerging evidence points to …

Differentiation induces the formation of noncentrosomal microtubule arrays in diverse
tissues. The formation of these arrays requires loss of microtubule-organizing activity …

More than 100 human genetic skin diseases, impacting over 20% of the population, are
characterized by disrupted epidermal differentiation. A significant proportion of the 90 genes …