The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as
either promoters or inhibitors of cell death. The functional interplay and balance between the …

The discovery of alternative signaling pathways that regulate cell death has revealed
multiple strategies for promoting cell death with diverse consequences at the tissue and …

Abstract During apoptosis, the BCL‐2‐family protein tBID promotes mitochondrial
permeabilization by activating BAX and BAK and by blocking anti‐apoptotic BCL‐2 …

BOK is a poorly understood member of the BCL-2 family of proteins that has been proposed
to function as a pro-apoptotic, BAX-like effector. However, the molecular mechanism and …

The prosurvival Bcl-2 family proteins Mcl-1 and Bcl-xL inhibit apoptosis by sequestering BH3-
only proteins such as Bid and Bim (MODE 1) or the effector proteins Bak and Bax (MODE 2) …

The proteins of the BCL2 family are key players in multiple cellular processes, chief amongst
them being the regulation of mitochondrial integrity and apoptotic cell death. These proteins …

BOK is an evolutionarily conserved BCL-2 family member that resembles the apoptotic
effectors BAK and BAX in sequence and structure. Based on these similarities, BOK has …

Lipids are fundamental to life as structural components of cellular membranes and for
signaling. They are also key regulators of different cellular processes such as cell division …

Despite intensive research effort, how the paradigmatic proapoptotic protein BAX forms
lethal apoptotic pores at the mitochondrial outer membrane (MOM) remains incompletely …

Proteins belonging to the BCL2 family are key modulators of apoptosis that establish a
complex network of interactions among themselves and with other cellular factors to regulate …