The synthesis, the antitumor activity, the SAR and, whenever described, the possible mode
of action of 1, 2, 4-triazine derivatives, their N-oxides, N, N′-dioxides as well as the benzo …

Acenaphthylene-1, 2-dione has been utilized in a wide range of reactions as a starting
material for the synthesis of hetero-and carbocyclic compounds and complexes. This review …

Multicomponent reactions (MCRs) have been widely used in modern organic synthesis and
medicinal chemistry. Multicomponent reactions are one-pot processes with three or more …

Cancer is one of the main global health problems. In order to develop novel antitumor
agents, we synthesized 3, 4-dihydropyrimidine-2 (1H)-one (DHPM) and 2, 6-diaryl …

A series of novel bis (indolyl) methane-β-lactam hybrids has been efficiently synthesized by
a [2+ 2]-cycloaddition reaction of imines 5a-c with ketenes derived from substituted acetic …

An efficient one‐pot multicomponent double Michael addition strategy was developed for the
synthesis of novel curcumin derivatives using 1, 4‐diazabicyclo [2.2. 2] octane (DABCO) as …

Abstract c-Met receptor tyrosine kinase has recently emerged as an important target with
therapeutic implications in pancreatic cancer. In this study, we carried out a docking virtual …

Apoptosis (programmed cell death) is a process by which cells died after completing
physiological function or after a severe genetic damage. Apoptosis is mainly regulated by …

Abstract Novel phenanthro-triazine-3-thiol derivatives were designed as potential DNA
intercalators and Bcl-2 inhibitors. After being synthesized, the compounds were evaluated …

Current research based on the development of promising anticancer chemotherapeutics is a
great challenge to scientists to combat the pervasiveness of pernicious cancer. In line with …