Gut microbiota-gonadal axis: the impact of gut microbiota on reproductive functions

VJ Ashonibare, BA Akorede, PJ Ashonibare… - Frontiers in …, 2024 - frontiersin.org
The influence of gut microbiota on physiological processes is rapidly gaining attention
globally. Despite being under-studied, there are available data demonstrating a gut …

Pathophysiology and management of testicular ischemia/reperfusion injury: Lessons from animal models

RE Akhigbe, AF Odetayo, TM Akhigbe, MA Hamed… - Heliyon, 2024 - cell.com
Testicular torsion is a urological emergency that involves the twisting of the spermatic cord
along its course. Compelling pieces of evidence have implicated oxidative stress-sensitive …

Acetate Abates Arsenic-Induced Male Reproductive Toxicity by Suppressing HDAC and Uric Acid–Driven Oxido-inflammatory NFkB/iNOS/NO Response in Rats

EE Besong, TM Akhigbe, JN Obimma… - … Trace Element Research, 2024 - Springer
Arsenic is associated with male reproductive toxicity through histone deacetylation and
oxido-inflammatory injury. Notwithstanding, short-chain fatty acids such as acetate exert anti …

Orange peel extract and physical exercise synergistically ameliorate type 2 diabetes mellitus-induced dysmetabolism by upregulating GLUT4 concentration in male …

LA Olayaki, KB Okesina, JD Jesubowale… - Journal of Medicinal …, 2023 - liebertpub.com
Diabetes mellitus (DM) is a chronic disease and one of the oldest known disorders. It is
characterized by dysglycemia, dyslipidemia, insulin resistance (IR), and pancreatic cell …

In vivo exposure to bisphenol F induces oxidative testicular toxicity: role of Erβ and p53/Bcl-2 signaling pathway

AF Odetayo, WJ Adeyemi, LA Olayaki - Frontiers in Reproductive …, 2023 - frontiersin.org
Introduction Bisphenol F (BPF), an alternative to bisphenol A has been implicated as a
gonadotoxic substance. BPF has been shown to induce hormonal imbalance and testicular …

Omega-3 fatty acid ameliorates bisphenol F-induced testicular toxicity by modulating Nrf2/NFkB pathway and apoptotic signaling

AF Odetayo, WJ Adeyemi, LA Olayaki - Frontiers in Endocrinology, 2023 - frontiersin.org
Introduction Bisphenol F (BPF) has been shown to disrupt testicular functions via
perturbation of testicular redox balance, while omega-3 fatty acid (O3FA) has been …

Naringin prevents diabetic-induced dysmetabolism in male wistar rats by modulating GSK-3 activities and oxidative stress-dependent pathways

KB Okesina, AF Odetayo, WJ Adeyemi… - Cell biochemistry and …, 2024 - Springer
Type 2 diabetes mellitus (T2DM), characterized by insulin resistance and glucose
dysmetabolism, is a major metabolic disorder accompanied with health and financial …

Glutamine alleviates I/R-Induced intestinal injury and dysmotility via the downregulation of xanthine oxidase/uric acid signaling and lactate generation in wistar rats

RE Akhigbe, BOA Aminat, TM Akhigbe… - Journal of Surgical …, 2024 - Elsevier
Introduction Disruption of intestinal histoarchitecture and intestinal dysmotility is critical to
intestinal ischemia/reperfusion (IR) injury and xanthine oxidase (XO)/uric acid (UA) signaling …

Omega 3 fatty acids preserve testicular function by ameliorating BPF-induced dysthyroidism: role of p53/Bcl-2 signaling and proton pump activities

AF Odetayo, LA Olayaki - JBRA assisted reproduction, 2024 - pmc.ncbi.nlm.nih.gov
Objective Bisphenol F (BPF) is an endocrinedisrupting chemical, but information about its
effect on thyroid hormones has not been fully explored. Omega 3 fatty acids (O3FA), on the …

Glutamine-mediated modulation of XO/uric acid/NF-kB signaling pathway ameliorates intestinal I/R-induced bacterial translocation and Cardiorenal inflammatory …

MA Hamed, OO Adegboyega, OI Ojo… - Cell Biochemistry and …, 2024 - Springer
This study explored the effect of intestinal ischaemia/reperfusion (I/R) on cardiorenal tissues.
The involvement of xanthine oxidase/uric acid/NF-kB signaling in intestinal I/R was also …