In the era of big data, transformation of biomedical big data into valuable knowledge has
been one of the most important challenges in bioinformatics. Deep learning has advanced …

Long noncoding RNAs (lncRNAs) are emerging as a class of important regulators
participating in various biological functions and disease processes. With the widespread …

Nucleosome organization is critical for gene regulation. In living cells this organization is
determined by multiple factors, including the action of chromatin remodellers, competition …

We present the first complete high-resolution map of nucleosome occupancy across the
whole Saccharomyces cerevisiae genome, identifying over 70,000 positioned nucleosomes …

Background The relative preference of nucleosomes to form on individual DNA sequences
plays a major role in genome packaging. A wide variety of DNA sequence features are …

Positioned nucleosomes limit the access of proteins to DNA and implement regulatory
features encoded in eukaryotic genomes. Here we have generated the first genome-wide …

The vast majority of the genetic variants (mainly SNPs) associated with various human traits
and diseases map to a noncoding part of the genome and are enriched in its regulatory …

During the past decade, user privacy has become an important issue in networked
computing environments. For instance, mobile applications and devices are increasingly …

▪ Abstract Structural data on protein-DNA complexes provide clues for understanding the
mechanism of protein-DNA recognition. Although the structures of a large number of protein …

Background There has been a growing interest in computational discovery of regulatory
elements, and a multitude of motif discovery methods have been proposed. Computational …