Metformin and cancer hallmarks: shedding new lights on therapeutic repurposing
Y Hua, Y Zheng, Y Yao, R Jia, S Ge… - Journal of Translational …, 2023 - Springer
Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …
Is it still worth pursuing the repurposing of metformin as a cancer therapeutic?
Over the past 15 years, there has been great interest in the potential to repurpose the
diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts …
diabetes drug, metformin, as a cancer treatment. However, despite considerable efforts …
STAT3 pathway in cancers: Past, present, and future
HQ Wang, QW Man, FY Huo, X Gao, H Lin, SR Li… - MedComm, 2022 - Wiley Online Library
Signal transducer and activator of transcription 3 (STAT3), a member of the STAT family,
discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in …
discovered in the cytoplasm of almost all types of mammalian cells, plays a significant role in …
Repurposing metformin for the prevention of cancer and cancer recurrence
BM Heckman-Stoddard, A DeCensi… - Diabetologia, 2017 - Springer
Multiple epidemiological studies have documented an association between metformin, used
for treatment of type 2 diabetes, and reduced cancer incidence and mortality. Cell line …
for treatment of type 2 diabetes, and reduced cancer incidence and mortality. Cell line …
Metabolic coupling and the Reverse Warburg Effect in cancer: Implications for novel biomarker and anticancer agent development
L Wilde, M Roche, M Domingo-Vidal, K Tanson… - Seminars in …, 2017 - Elsevier
abstract Glucose is a key metabolite used by cancer cells to generate ATP, maintain redox
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …
state and create biomass. Glucose can be catabolized to lactate in the cytoplasm, which is …
[HTML][HTML] Tumor microenvironment in head and neck squamous cell carcinoma: Functions and regulatory mechanisms
G Wang, M Zhang, M Cheng, X Wang, K Li, J Chen… - Cancer Letters, 2021 - Elsevier
The tumor microenvironment has been recently reported to play a pivotal role in sustaining
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …
tumor cells survival and protecting them from immunotherapy and chemotherapy-induced …
Metformin and cancer, an ambiguanidous relationship
The deregulation of energetic and cellular metabolism is a signature of cancer cells. Thus,
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …
drugs targeting cancer cell metabolism may have promising therapeutic potential. Previous …
Targeting of the tumor immune microenvironment by metformin
Z Wu, C Zhang, M Najafi - Journal of cell communication and signaling, 2022 - Springer
Stimulating antitumor immunity is an attractive idea for suppressing tumors. CD4+ and CD8+
T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor …
T cells as well as natural killer cells (NK) are the primary antitumor immune cells in the tumor …
Fructose 2, 6-bisphosphate in cancer cell metabolism
R Bartrons, H Simon-Molas, A Rodríguez-García… - Frontiers in …, 2018 - frontiersin.org
For a long time, pioneers in the field of cancer cell metabolism, such as Otto Warburg, have
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …
focused on the idea that tumor cells maintain high glycolytic rates even with adequate …
Repurposing drugs targeting metabolic diseases for cancer therapeutics
Highlights•Discovery of new drugs against cancer is of utmost importance.•Drug repurposing
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …
is an alternative approach to traditional drug discovery.•It significantly reduces the R&D …