Peptides are fragments of proteins that carry out biological functions. They act as signaling
entities via all domains of life and interfere with protein-protein interactions, which are …

Alzheimer's disease (AD) is a major form of dementia, closely associated with the
filamentous assembly of amyloid-β (Aβ) and Tau protein in the brain, which can cause …

Self-assembling peptides are being applied both in the biomedical area and as building
blocks in nanotechnology. Their applications are closely linked to their modes of self …

Amyloid beta (Aβ) peptide aggregates rapidly into the soluble oligomers, protofibrils and
fibrils to form senile plaques, a neurotoxic component and pathological hallmark of …

Protein misfolding and aggregation can be induced by a wide variety of factors, such as
dominant disease-associated mutations, changes in the environmental conditions (pH …

After three decades of false hopes and failures, a pipeline of therapeutic drugs that target the
actual root cause of Alzheimer's disease (AD) is now available. Challenging the old …

Protein aggregation is now recognized as a generic and significant component of the protein
energy landscape. Occurring through a complex and dynamic pathway of structural …

The pathological aggregation of α-synuclein (αS) into amyloid fibrils is the hallmark of
Parkinson's disease (PD). The self-assembly and membrane interactions of αS are mainly …

Amyloid fibrils, insoluble β‐sheets structures that arise from protein misfolding, are
associated with several neurodegenerative disorders. Many small molecules have been …

Inhibition of fibril formation is considered a possible treatment strategy for amyloid-related
diseases. Understanding the molecular nature of inhibitor action is crucial for the design of …