Systemic lupus erythematosus (SLE) is a disease characterized by dysregulation and
hyperreactivity of the immune response at various levels, including hyperactivation of …

Systemic lupus erythematosus (SLE) is a very complex disease where multiple
immunological pathways can concur in inducing tissue damage. Cytokines are key …

CD4+ T cells are important drivers of tissue damage in immune-mediated renal diseases,
such as anti-glomerular basement membrane glomerulonephritis, anti-neutrophil …

The IL-17 cytokine family and the cognate receptors thereof have a unique role in organ-
specific autoimmunity. Most studies have focused on the founding member of the IL-17 …

Abstract Interleukin 17A (IL-17A) and complement (C′) activation have each been
implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). We have reported that …

Background IL-17A–producing CD4+ T helper (TH 17) cells play a critical role in
autoimmune and chronic inflammatory diseases, such as crescentic GN. The …

The kidney is an organ particularly susceptible to damage caused by infections and
autoimmune conditions. Renal inflammation confers protection against microbial infections …

Gammaherpesviruses, such as human Epstein-Barr virus (EBV) and murine
gammaherpesvirus 68 (MHV68), are species-specific, ubiquitous pathogens that are …

Chronic antibody mediated rejection (AMR) is the major cause of solid organ graft rejection.
Th17 contributes to AMR through the secretion of IL17A, IL21 and IL22. These cytokines …

Extraintestinal autoimmune diseases are multifactorial with translocating gut pathobionts
implicated as instigators and perpetuators in mice. However, the microbial contributions to …