Primary biliary cholangitis

A Lleo, GQ Wang, ME Gershwin, GM Hirschfield - The Lancet, 2020 - thelancet.com
Primary biliary cholangitis is an autoimmune liver disease that predominantly affects women.
It is characterised by a chronic and destructive, small bile duct, granulomatous lymphocytic …

Primary biliary cholangitis: Epidemiology, prognosis, and treatment

J Trivella, BV John, C Levy - Hepatology communications, 2023 - journals.lww.com
Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune liver disease
characterized by a destructive, small duct, and lymphocytic cholangitis, and marked by the …

EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis

GM Hirschfield, U Beuers, C Corpechot, P Invernizzi… - Journal of …, 2017 - Elsevier
Primary biliary cholangitis (PBC) is a chronic inflammatory autoimmune cholestatic liver
disease, which when untreated will culminate in end-stage biliary cirrhosis. Diagnosis is …

Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis

TJ Weismüller, PJ Trivedi, A Bergquist, M Imam… - Gastroenterology, 2017 - Elsevier
Background & Aims Primary sclerosing cholangitis (PSC) is an orphan hepatobiliary
disorder associated with inflammatory bowel disease (IBD). We aimed to estimate the risk of …

The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines

GM Hirschfield, JK Dyson, GJM Alexander… - Gut, 2018 - gut.bmj.com
Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an
autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury …

[HTML][HTML] Efficacy of obeticholic acid in patients with primary biliary cirrhosis and inadequate response to ursodeoxycholic acid

GM Hirschfield, A Mason, V Luketic, K Lindor… - Gastroenterology, 2015 - Elsevier
Background & Aims We evaluated the efficacy and safety of obeticholic acid (OCA, α-
ethylchenodeoxycholic acid) in a randomized controlled trial of patients with primary biliary …

APASL clinical practice guidance: the diagnosis and management of patients with primary biliary cholangitis

H You, X Ma, C Efe, G Wang, SH Jeong, K Abe… - Hepatology …, 2022 - Springer
Hong You1· Xiong Ma2· Cumali Efe3· Guiqiang Wang4· Sook‑Hyang Jeong5· Kazumichi
Abe6· Weijia Duan1· Sha Chen1· Yuanyuan Kong7· Dong Zhang8· Lai Wei9· Fu‑Sheng …

Development and validation of a scoring system to predict outcomes of patients with primary biliary cirrhosis receiving ursodeoxycholic acid therapy

WJ Lammers, GM Hirschfield, C Corpechot, F Nevens… - Gastroenterology, 2015 - Elsevier
Background & Aims Approaches to risk stratification for patients with primary biliary cirrhosis
(PBC) are limited, single-center based, and often dichotomous. We aimed to develop and …

Real impact of liver cirrhosis on the development of hepatocellular carcinoma in various liver diseases—meta‐analytic assessment

K Tarao, A Nozaki, T Ikeda, A Sato, H Komatsu… - Cancer …, 2019 - Wiley Online Library
Background It is well known that the incidence of developing hepatocelluler carcinoma
(HCC) is increased in liver cirrhosis of different etiologies. However, comparison of HCC …

Primary biliary cirrhosis

EJ Carey, AH Ali, KD Lindor - The Lancet, 2015 - thelancet.com
Primary biliary cirrhosis is a chronic cholestatic liver disease characterised by destruction of
small intrahepatic bile ducts, leading to fibrosis and potential cirrhosis through resulting …