BackgroundAnxiety has been associated with new-onset cardiovascular disease (CVD), but
the quality of this relationship is unclear. Only if anxiety is a causal, independent …

We present a comprehensive overview of the neurobiology of unipolar major depression
and antidepressant drug action, integrating data from affective neuroscience, neuro-and …

The hypothalamic–pituitary–adrenal (HPA) axis and the inflammatory response system have
been suggested as pathophysiological mechanisms implicated in the etiology of major …

Introduction The heterogeneity of symptoms and complex etiology of depression pose a
significant challenge to the personalization of treatment. Meanwhile, the current application …

Major Depressive Disorder (MDD) is a highly prevalent psychiatric disorder worldwide. It
causes individual suffering, loss of productivity, increased health care costs and high suicide …

Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

Cholesterol is an essential component of eukaryotic membranes and plays a crucial role in
membrane organization, dynamics and function. The modulatory role of cholesterol in the …

A number of studies have examined the association between diet and mood state, but the
findings have been inconclusive. Herein, we conducted a systematic review to assess the …

Serotonin is an intrinsically fluorescent biogenic amine that acts as a neurotransmitter and is
found in a wide variety of sites in the central and peripheral nervous system. Serotonergic …

Conventional antidepressants are widely employed in several psychiatric and neurologic
disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are …