For many years, adipose tissue was considered as an inert energy storage organ that
accumulates and stores triacylglycerols during energy excess and releases fatty acids in …

Cardiovascular disease (CVD) is a serious health challenge, causing more deaths
worldwide than cancer. The vascular endothelium, which forms the inner lining of blood …

Apelin, an endogenous ligand for the G protein–coupled receptor (APJ), is widely distributed
within the central nervous system and diverse organs in human and animals. Recent studies …

Atherosclerosis is a chronic inflammatory disease of the arterial wall with lipid-laden lesions,
involving a complex interaction between multiple different cell types and cytokine networks …

Apelin is an adipokine that has been identified as an endogenous ligand for the orphan
receptor APJ. Apelin and APJ are expressed in a diverse range of tissues with particular …

Background/Aims: Acute lung injury (ALI) is induced by a variety of external and internal
factors and leads to acute progressive respiratory failure. Previous studies have shown that …

Abstract Purpose of Review The aim of this review is to overview the pathophysiological role
of adipocytokines in atherogenesis, focusing on their potential role as biomarkers of …

The metastasis suppressor, N-myc downstream regulated gene 1 (NDRG1), is negatively
correlated with tumor progression in multiple neoplasms, being a promising new target for …

Apelin, the endogenous ligand of APJ which is a member of G protein-coupled receptors,
has been shown to be expressed in a variety of tissues in vivo and to exert significant …

Whereas the role of the G-protein-coupled APJ receptor and its ligand, apelin, in
angiogenesis has been well documented, the ability of the apelin/APJ system to induce …