Granule cells of the cerebellum constitute the largest homogeneous neuronal population of
mammalian brain. Due to their postnatal generation and the feasibility of well characterized …

The Na+, K+-ATPase is a ubiquitous membrane transport protein in mammalian cells,
responsible for establishing and maintaining high K+ and low Na+ in the cytoplasm required …

The plant-derived steroid, digoxin, a specific inhibitor of Na, K-ATPase, has been used for
centuries in the treatment of heart disease. Recent studies demonstrate the presence of a …

This study extended the findings of Ketten et al.[Ann. Otol. Rhinol. Laryngol. Suppl. 175: 1–
16 (1998)] by estimating the three-dimensional (3D) cochlear lengths, electrode array …

Energy deficiency and dysfunction of the Na+, K+-ATPase are common consequences of
many pathological insults. The nature and mechanism of cell injury induced by impaired …

Background Stroke is a leading cause of long-term disability. All neuroprotectants targeting
excitotoxicity have failed to become stroke medications. In order to explore and identify new …

Na, K-ATPase is a protein ubiquitously expressed in the plasma membrane of all animal
cells and vitally essential for their functions. A specialized functional diversity of the Na, K …

We report here the results of a chemical genetic screen using small molecules with known
pharmacologies coupled with a cortical brain slice-based model for ischemic stroke. We …

To determine the therapeutic potential of cardiac glycosides in androgen-independent
prostate cancer, we examined ouabain-induced cytotoxic effect as well as the signaling …

The physiological and morphological changes resulting from acute and chronic infusion of
ouabain onto the intact round-window (RW) membrane were examined in the gerbil …