Bioinformatic analysis can not only accelerate drug target identification and drug candidate
screening and refinement, but also facilitate characterization of side effects and predict drug …

Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …

Ubiquitination and deubiquitination play a critical role in all aspects of cellular processes,
and the enzymes involved are tightly regulated by multiple factors including posttranslational …

DAMBE is a comprehensive software workbench for data analysis in molecular biology,
phylogenetics, and evolution. Several important new functions have been added since …

Background USP11 is an ubiquitin-specific protease that plays an important role in tumor
progression via different mechanisms. However, the expression and prognostic significance …

Abstract Poly-(ADP-ribose) polymerase inhibitors (PARPi) selectively kill breast and ovarian
cancers with defects in homologous recombination (HR) caused by BRCA1/2 mutations …

Altered lipid metabolism and aberrant protein translation are strongly associated with
cancerous outgrowth; however, the inter-regulation of these key processes is still …

Background Tropical stenothermal fish exhibit special tolerance and response to cold stress.
However current knowledge of the molecular mechanisms response to cold stress in aquatic …

RBM10 is a nuclear RNA-binding protein (RBP) that regulates the alternative splicing of
primary transcripts. Recently, research on RBM10 has become increasingly active owing to …

Abstract Background He-Chan Pian (HCP), a traditional Chinese medicinal formula, shows
promising efficacy for the treatment of lung cancer. Purpose Gremlin (GREM1) plays an …