Recent functional insights into the role of (p) ppGpp in bacterial physiology
The alarmones guanosine tetraphosphate and guanosine pentaphosphate (collectively
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
referred to as (p) ppGpp) are involved in regulating growth and several different stress …
Translation in prokaryotes
MV Rodnina - Cold Spring Harbor perspectives in …, 2018 - cshperspectives.cshlp.org
This review summarizes our current understanding of translation in prokaryotes, focusing on
the mechanistic and structural aspects of each phase of translation: initiation, elongation …
the mechanistic and structural aspects of each phase of translation: initiation, elongation …
Multifaceted roles of methylisothiazolinone intervention in sludge disintegration and acidogenic and methanogenic pathways for efficient carboxylate production …
S Fang, W Cao, Q Wu, S Cheng, Y Yang, J Liu… - Chemical Engineering …, 2023 - Elsevier
Anaerobic fermentation is a promising approach for sludge treatment, although it is
frequently hindered by the tight structure of extracellular polymeric substances (EPS) and …
frequently hindered by the tight structure of extracellular polymeric substances (EPS) and …
tRNA modifications: impact on structure and thermal adaptation
C Lorenz, CE Lünse, M Mörl - Biomolecules, 2017 - mdpi.com
Transfer RNAs (tRNAs) are central players in translation, functioning as adapter molecules
between the informational level of nucleic acids and the functional level of proteins. They …
between the informational level of nucleic acids and the functional level of proteins. They …
Tetracycline antibiotics and resistance mechanisms
F Nguyen, AL Starosta, S Arenz, D Sohmen… - Biological …, 2014 - degruyter.com
The ribosome and protein synthesis are major targets within the cell for inhibition by
antibiotics, such as the tetracyclines. The tetracycline family of antibiotics represent a large …
antibiotics, such as the tetracyclines. The tetracycline family of antibiotics represent a large …
Structural basis of early translocation events on the ribosome
Peptide-chain elongation during protein synthesis entails sequential aminoacyl-tRNA
selection and translocation reactions that proceed rapidly (2–20 per second) and with a low …
selection and translocation reactions that proceed rapidly (2–20 per second) and with a low …
Biosynthesis of polyketides by trans-AT polyketide synthases
EJN Helfrich, J Piel - Natural product reports, 2016 - pubs.rsc.org
Covering 2000 to June 2015 This review discusses the biosynthesis of natural products that
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …
are generated by trans-AT polyketide synthases, a family of catalytically versatile enzymes …
Structure of the E. coli ribosome–EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM
Single particle electron cryomicroscopy (cryo-EM) has recently made significant progress in
high-resolution structure determination of macromolecular complexes due to improvements …
high-resolution structure determination of macromolecular complexes due to improvements …
The elongation, termination, and recycling phases of translation in eukaryotes
This work summarizes our current understanding of the elongation and termination/recycling
phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In …
phases of eukaryotic protein synthesis. We focus here on recent advances in the field. In …
Ribosomal stress-surveillance: three pathways is a magic number
AC Vind, AV Genzor, S Bekker-Jensen - Nucleic acids research, 2020 - academic.oup.com
Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative
effects of harmful environmental stimuli. The stress-and mitogen-activated protein (MAP) …
effects of harmful environmental stimuli. The stress-and mitogen-activated protein (MAP) …