The classical role of AMP-activated protein kinase (AMPK) is as a cellular energy sensor
activated by falling energy status, signalled by increases in AMP to ATP and ADP to ATP …

Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …

The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …

Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Sodium–glucose cotransporter 2 inhibitors (SGLT2i) have favorable cardiovascular
outcomes in patients with diabetes. However, whether SGLT2i can improve obesity-related …

Recent evidence shows that resveratrol (RSV) may ameliorate high-glucose-induced
cardiac oxidative stress, mitochondrial dysfunction and myocardial fibrosis in diabetes …

Autophagy is an evolutionarily conserved process that plays a crucial role in maintaining a
series of cellular functions. It has been found that autophagy is closely involved in the …

Cardiac fibrosis is one of the main characteristics of diabetic cardiomyopathy and manifests
excessive accumulation of extracellular matrix proteins in the heart. Several signaling …

Cardiac remodeling, which is characterized by mechanical and electrical remodeling, is a
significant pathophysiological process involved in almost all forms of heart diseases …

The prevalence of type 2 diabetes (T2D) has reached a pandemic scale. These patients are
at a substantially elevated risk of developing cardiovascular disease, with heart failure (HF) …