Reaction Mechanism of Cytochrome c Oxidase

S Yoshikawa, A Shimada - Chemical reviews, 2015 - ACS Publications
Cytochrome c oxidase (CcO), the terminal oxidase of cell respiration, reduces molecular
oxygen (O2) in a reaction that is coupled with proton pumping. Since the discovery of this …

Cytochrome c Oxidase:  Catalytic Cycle and Mechanisms of Proton Pumping-A Discussion

H Michel - Biochemistry, 1999 - ACS Publications
Cytochrome c oxidase catalyzes the reduction of molecular oxygen to water, a process in
which four electrons, four protons, and one molecule of oxygen are consumed. The reaction …

[HTML][HTML] Absorption measurements of a cell monolayer relevant to phototherapy: reduction of cytochrome c oxidase under near IR radiation

TI Karu, LV Pyatibrat, SF Kolyakov… - Journal of Photochemistry …, 2005 - Elsevier
Phototherapy uses monochromatic light in the optical region of 600–1000nm to treat in a
non-destructive and non-thermal fashion various soft-tissue and neurological conditions …

The roles of the two proton input channels in cytochrome c oxidase from Rhodobacter sphaeroides probed by the effects of site-directed mutations on time-resolved …

AA Konstantinov, S Siletsky… - Proceedings of the …, 1997 - National Acad Sciences
The crystal structures of cytochrome c oxidase from both bovine and Paracoccus
denitrificans reveal two putative proton input channels that connect the heme-copper center …

A Novel Mitochondrial Signaling Pathway Activated by Visible‐to‐near Infrared Radiation

TI Karu, LV Pyatibrat… - Photochemistry and …, 2004 - Wiley Online Library
The number of cells attached to glass substratum increases if HeLa cell suspension is
irradiated with monochromatic visible‐to‐near infrared radiation before plating (the action …

A mechanistic principle for proton pumping by cytochrome c oxidase

K Faxén, G Gilderson, P Ädelroth, P Brzezinski - Nature, 2005 - nature.com
In aerobic organisms, cellular respiration involves electron transfer to oxygen through a
series of membrane-bound protein complexes. The process maintains a transmembrane …

Exploring the proton pump mechanism of cytochrome c oxidase in real time

I Belevich, DA Bloch, N Belevich… - Proceedings of the …, 2007 - National Acad Sciences
Cytochrome c oxidase catalyzes most of the biological oxygen consumption on Earth, a
process responsible for energy supply in aerobic organisms. This remarkable membrane …

The catalytic cycle of cytochrome c oxidase is not the sum of its two halves

D Bloch, I Belevich, A Jasaitis… - Proceedings of the …, 2004 - National Acad Sciences
Membrane-bound cytochrome c oxidase catalyzes cell respiration in aerobic organisms and
is a primary energy transducer in biology. The two halves of the catalytic cycle may be …

The mechanism of proton pumping by cytochrome c oxidase

H Michel - Proceedings of the National Academy of …, 1998 - National Acad Sciences
Cytochrome c oxidase catalyzes the reduction of oxygen to water that is accompanied by
pumping of four protons across the mitochondrial or bacterial membrane. Triggered by the …

Multiple proton-conducting pathways in cytochrome oxidase and a proposed role for the active-site tyrosine

RB Gennis - Biochimica et Biophysica Acta (BBA)-Bioenergetics, 1998 - Elsevier
During each turnover of cytochrome oxidase (dioxygen reduced to water), eight protons are
taken up from the inside of the membrane, four protons being used for chemistry (water …