Integrating spatial transcriptomics and single-cell RNA-sequencing reveals the alterations in epithelial cells during nodular formation in benign prostatic hyperplasia
X Fei, J Liu, J Xu, H Jing, Z Cai, J Yan, Z Wu… - Journal of Translational …, 2024 - Springer
Objective Proliferative nodular formation represents a characteristic pathological feature of
benign prostatic hyperplasia (BPH) and serves as the primary cause for prostate volume …
benign prostatic hyperplasia (BPH) and serves as the primary cause for prostate volume …
Emerging roles for LGR4 in organ development, energy metabolism and carcinogenesis
L Yang, J Wang, X Gong, Q Fan, X Yang, Y Cui… - Frontiers in …, 2022 - frontiersin.org
The leucine-rich repeats containing G protein-coupled receptor 4 (LGR4) belonging to G
protein-coupled receptors (GPCRs) family, had various regulatory roles at multiple cellular …
protein-coupled receptors (GPCRs) family, had various regulatory roles at multiple cellular …
A novel co-culture model of human prostate epithelial and stromal cells for androgenic and antiandrogenic screening
H Li, S Madnick, H Zhao, S Hall, A Amin, MP Dent… - Toxicology in Vitro, 2023 - Elsevier
The risk assessment of endocrine-disrupting chemicals (EDCs) greatly relies on in vitro
screening. A 3-dimensional (3D) in vitro prostate model that can reflect physiologically …
screening. A 3-dimensional (3D) in vitro prostate model that can reflect physiologically …
BPA-induced prostatic hyperplasia in vitro is correlated with the unbalanced gene expression of AR and ER in the epithelium and stroma
K Wang, D Huang, P Zhou, X Su… - Toxicology and …, 2021 - journals.sagepub.com
As a typical environmental endocrine disruptor (EED), bisphenol A (BPA) can induce
pathological hyperplasia of the prostatic epithelium and stroma. This study concentrates …
pathological hyperplasia of the prostatic epithelium and stroma. This study concentrates …
New fusidane-type nortriterpenoids from the Arctic marine-derived fungus Simplicillium lamellicola culture medium with their inhibitory effect on benign prostatic …
H Kwon, BR Jin, S Yoo, HJ Kim, BY Hwang, Y Guo… - Bioorganic …, 2024 - Elsevier
Three new fusidane-type nortriterpenoids, simplifusinolide A, 24-epi simplifusinolide A, and
simplifusidic acid L (1–3), were isolated from the EtOAc extract of the Arctic marine-derived …
simplifusidic acid L (1–3), were isolated from the EtOAc extract of the Arctic marine-derived …
Shikonin alleviates testosterone-induced benign prostatic hyperplasia in rats via the Nrf2-ARE and NF-κB pathway
Z Ma, Z Wang, C Xu, M Jiang - Molecular & Cellular Toxicology, 2024 - Springer
Background Benign prostatic hyperplasia (BPH) is a prevalent and chronic progressive
disease in aging males with lower urinary tract symptoms. Shikonin is known as traditional …
disease in aging males with lower urinary tract symptoms. Shikonin is known as traditional …
Delineating how PI3K/PTEN oncogenic signalling contributes to prostate cancer
M Mullen - 2021 - orca.cardiff.ac.uk
In 2020, an estimated 19.3 million new cancer cases were diagnosed, 7.3% of which were
cancer of the prostate. It is evident that the development of prostate tumours is highly …
cancer of the prostate. It is evident that the development of prostate tumours is highly …
The Association of Steroid 5-Alpha Reductase Type 2 and Estrogen Receptors in the Prostate
C Sharkey - 2021 - search.proquest.com
Benign prostatic hyperplasia (BPH) continues to remain a significant health problem. Steroid
5α-reductase 2 (SRD5A2) is the predominant enzyme responsible for prostatic development …
5α-reductase 2 (SRD5A2) is the predominant enzyme responsible for prostatic development …