Despite advances in neurosurgery, chemotherapy and radiotherapy, glioblastoma remains
one of the most treatment-resistant CNS malignancies, and the tumour inevitably recurs. The …

Abstract Non‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a
unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) …

Titanium dioxide (TiO 2) is a frequently used biomaterial, particularly in orthopedic and
dental implants, and it is considered an inert and benign compound. This has resulted in …

Background Irreversible electroporation (IRE) has been previously investigated in preclinical
trials as a treatment for intracranial malignancies. Here, we investigate next generation high …

Background Pharmacological treatment of CNS diseases is limited due to the presence of
the blood-brain barrier (BBB). Recent years showed significant advancement in the field of …

Abstract Electroporation-based therapy (EBT), as a high-voltage-pulse technology has been
prevalent with favorable clinical outcomes in the treatment of various solid tumors. This …

Multiple chemodrugs with nanotechnology have proven to be an effective cancer treatment
technique. When taken combined, cabazitaxel (CTX) and cisplatin (PT) have more excellent …

The treatment of CNS disorders suffers from the inability to deliver large therapeutic agents
to the brain parenchyma due to protection from the blood-brain barrier (BBB). Herein, we …

The blood–brain barrier (BBB) is a major hurdle for the treatment of central nervous system
disorders, limiting passage of both small and large therapeutic agents from the blood stream …

High-voltage pulsed electric fields (HV-PEF) delivered with invasive needle electrodes for
electroporation applications is known to induce off-target blood–brain barrier (BBB) …