Phase separation in immune signalling
Immune signalling pathways convert pathogenic stimuli into cytosolic events that lead to the
resolution of infection. Upon ligand engagement, immune receptors together with their …
resolution of infection. Upon ligand engagement, immune receptors together with their …
[HTML][HTML] The control centers of biomolecular phase separation: how membrane surfaces, PTMs, and active processes regulate condensation
WT Snead, AS Gladfelter - Molecular cell, 2019 - cell.com
Biomolecular condensation is emerging as an essential process for cellular
compartmentalization. The formation of biomolecular condensates can be driven by liquid …
compartmentalization. The formation of biomolecular condensates can be driven by liquid …
Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications
Liquid–liquid phase separation (LLPS) facilitates the formation of condensed biological
assemblies with well-delineated physical boundaries, but without lipid membrane barriers …
assemblies with well-delineated physical boundaries, but without lipid membrane barriers …
Synergistic phase separation of two pathways promotes integrin clustering and nascent adhesion formation
Integrin adhesion complexes (IACs) are integrin-based plasma-membrane-associated
compartments where cells sense environmental cues. The physical mechanisms and …
compartments where cells sense environmental cues. The physical mechanisms and …
Full control of ligand positioning reveals spatial thresholds for T cell receptor triggering
Elucidating the rules for receptor triggering in cell–cell and cell–matrix contacts requires
precise control of ligand positioning in three dimensions. Here, we use the T cell receptor …
precise control of ligand positioning in three dimensions. Here, we use the T cell receptor …
Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation
The intrinsically disordered region (IDR) is a preserved signature of phytobacterial type III
effectors (T3Es). The T3E IDR is thought to mediate unfolding during translocation into the …
effectors (T3Es). The T3E IDR is thought to mediate unfolding during translocation into the …
A composition-dependent molecular clutch between T cell signaling condensates and actin
During T cell activation, biomolecular condensates form at the immunological synapse (IS)
through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP …
through multivalency-driven phase separation of LAT, Grb2, Sos1, SLP-76, Nck, and WASP …
Membrane-associated phase separation: organization and function emerge from a two-dimensional milieu
JA Ditlev - Journal of Molecular Cell Biology, 2021 - academic.oup.com
Liquid–liquid phase separation (LLPS) of biomolecules has emerged as an important
mechanism that contributes to cellular organization. Phase-separated biomolecular …
mechanism that contributes to cellular organization. Phase-separated biomolecular …
PLCγ1 promotes phase separation of T cell signaling components
The T cell receptor (TCR) pathway receives, processes, and amplifies the signal from
pathogenic antigens to the activation of T cells. Although major components in this pathway …
pathogenic antigens to the activation of T cells. Although major components in this pathway …
Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state
CC Lin, KM Suen, PA Jeffrey, L Wieteska, JA Lidster… - Molecular cell, 2022 - cell.com
The recruitment of signaling proteins into activated receptor tyrosine kinases (RTKs) to
produce rapid, high-fidelity downstream response is exposed to the ambiguity of random …
produce rapid, high-fidelity downstream response is exposed to the ambiguity of random …