Molecular probes for autofluorescence-free optical imaging

Y Jiang, K Pu - Chemical reviews, 2021 - ACS Publications
Optical imaging is an indispensable tool in clinical diagnostics and fundamental biomedical
research. Autofluorescence-free optical imaging, which eliminates real-time optical …

Metabolism of the endocannabinoid anandamide: open questions after 25 years

M Maccarrone - Frontiers in molecular neuroscience, 2017 - frontiersin.org
Cannabis extracts have been used for centuries, but its main active principle∆ 9-
tetrahydrocannabinol (THC) was identified about 50 years ago. Yet, it is only 25 years ago …

Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection

J Huang, X Chen, Y Jiang, C Zhang, S He, H Wang… - Nature Materials, 2022 - nature.com
Optical nanoparticles are promising diagnostic tools; however, their shallow optical imaging
depth and slow clearance from the body have impeded their use for in vivo disease …

Dual-Ratiometric Target-Triggered Fluorescent Probe for Simultaneous Quantitative Visualization of Tumor Microenvironment Protease Activity and pH in Vivo

T Ma, Y Hou, J Zeng, C Liu, P Zhang… - Journal of the …, 2018 - ACS Publications
The abnormal expression of tumor-associated proteases and lowered extracellular pH are
important signatures strongly associated with cancer invasion, progression, and metastasis …

Enzymatic assemblies disrupt the membrane and target endoplasmic reticulum for selective cancer cell death

Z Feng, H Wang, S Wang, Q Zhang… - Journal of the …, 2018 - ACS Publications
The endoplasmic reticulum (ER) is responsible for the synthesis and folding of a large
number of proteins, as well as intracellular calcium regulation, lipid synthesis, and lipid …

Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy

S Zhai, X Hu, Y Hu, B Wu, D Xing - Biomaterials, 2017 - Elsevier
Undesired physiological instability of nanocarriers and premature drug leakage during
blood circulation result in compromised therapeutic efficacy and severe side effects, which …

Nanoparticle regrowth enhances photoacoustic signals of semiconducting macromolecular probe for in vivo imaging

C Xie, X Zhen, Y Lyu, K Pu - Advanced Materials, 2017 - Wiley Online Library
Smart molecular probes that emit deep‐tissue penetrating photoacoustic (PA) signals
responsive to the target of interest are imperative to understand disease pathology and …

[HTML][HTML] Chemiluminescence and bioluminescence imaging for biosensing and therapy: in vitro and in vivo perspectives

Y Yan, P Shi, W Song, S Bi - Theranostics, 2019 - ncbi.nlm.nih.gov
Chemiluminescence (CL) and bioluminescence (BL) imaging technologies, which require
no external light source so as to avoid the photobleaching, background interference and …

Furin‐mediated self‐assembly of olsalazine nanoparticles for targeted Raman imaging of tumors

Y Yuan, P Raj, J Zhang, S Siddhanta… - Angewandte …, 2021 - Wiley Online Library
Olsalazine (Olsa) is a broad‐spectrum anti‐cancer agent acting as a DNA‐methylation
inhibitor. When conjugated to 2‐cyano‐6‐aminobenzothiazole and a peptide substrate …

Bioluminescent turn-on probe for sensing hypochlorite in vitro and in tumors

P Chen, Z Zheng, Y Zhu, Y Dong, F Wang… - Analytical …, 2017 - ACS Publications
Hypochlorite (ClO–) is one of the most important reactive oxygen species but using a BL
probe for its selective detection (or imaging) still remains challenging. Herein, we report a …