L-asparaginase production review: bioprocess design and biochemical characteristics
D Castro, ASC Marques, MR Almeida… - Applied microbiology …, 2021 - Springer
In the past decades, the production of biopharmaceuticals has gained high interest due to its
great sensitivity, specificity, and lower risk of negative effects to patients. Biopharmaceuticals …
great sensitivity, specificity, and lower risk of negative effects to patients. Biopharmaceuticals …
Biotechnological production and practical application of L-asparaginase enzyme
L-asparaginase is a vital enzyme of medical importance, and renowned as a
chemotherapeutic agent. The relevance of this enzyme is not only limited as an anti-cancer …
chemotherapeutic agent. The relevance of this enzyme is not only limited as an anti-cancer …
Biochemical characterization of extremozyme L-asparaginase from Pseudomonas sp. PCH199 for therapeutics
Abstract L-asparaginase (L-ASNase) from microbial sources is a commercially vital enzyme
to treat acute lymphoblastic leukemia. However, the side effects associated with the …
to treat acute lymphoblastic leukemia. However, the side effects associated with the …
Exploring current scenario and developments in the field of microbial L-asparaginase production and applications: A review
PG Patel, HZ Panseriya, AK Vala, BP Dave… - Process …, 2022 - Elsevier
L-asparaginase, an amidohydrolase that catalyses break down of L-asparagine into aspartic
acid and ammonia, is one of the most prominent biopharmaceuticals. L-asparaginase (LA) …
acid and ammonia, is one of the most prominent biopharmaceuticals. L-asparaginase (LA) …
Process development for scale-up production of a therapeutic L-asparaginase by Streptomyces brollosae NEAE-115 from shake flasks to bioreactor
NEA El-Naggar, H Moawad, NM El-Shweihy… - Scientific reports, 2019 - nature.com
L-asparaginase is a promising enzyme that has a wide range of significant applications
including cancer therapy and starchy food industries. The statistical design of Plackett …
including cancer therapy and starchy food industries. The statistical design of Plackett …
[HTML][HTML] Response surface methodological optimization of l-asparaginase production from the medicinal plant endophyte Acinetobacter baumannii ZAS1
KN Abhini, AB Rajan, KF Zuhara… - Journal of Genetic …, 2022 - Elsevier
Background This study targets the enhanced production of l-asparaginase, an antitumor
enzyme by Acinetobacter baumannii ZAS1. This organism is an endophyte isolated from the …
enzyme by Acinetobacter baumannii ZAS1. This organism is an endophyte isolated from the …
l‐asparaginase production and enhancement by Sarocladium strictum: In vitro evaluation of anti‐cancerous properties
Aims Utilization of l‐asparaginase has been one of the effective strategies for the treatment
of lymphoblastic leukaemia. Since the currently used bacterial l‐asparaginase causes side …
of lymphoblastic leukaemia. Since the currently used bacterial l‐asparaginase causes side …
Performance evaluation and yield optimization of L-glutaminase free L-asparaginase from seaweed-associated bacteria
DE Mathew, AK Vala, R Dineshkumar… - Bioresource Technology …, 2023 - Elsevier
Gracilaria dura associated bacterial diversity revealed 75 isolates, which were screened for
L-asparaginase (LA) production. Out of the three positive isolates, upon secondary …
L-asparaginase (LA) production. Out of the three positive isolates, upon secondary …
Studies on efficient production of a novel l-asparaginase by a newly isolated Pseudomonas resinovorans IGS-131 and its heterologous expression in Escherichia coli
In the current study, the production of novel glutaminase free l-asparaginase from a new
microbial source (Pseudomonas resinovorans IGS-131) is reported. Optimization of l …
microbial source (Pseudomonas resinovorans IGS-131) is reported. Optimization of l …
In vitro screening and in silico validation revealed key microbes for higher production of significant therapeutic enzyme l-asparaginase
Abstract l-asparaginase is an enzyme of medical prominence and reputable as a
chemotherapeutic agent. It also has immense potential to cure autoimmune and infectious …
chemotherapeutic agent. It also has immense potential to cure autoimmune and infectious …