L-asparaginase production review: bioprocess design and biochemical characteristics

D Castro, ASC Marques, MR Almeida… - Applied microbiology …, 2021 - Springer
In the past decades, the production of biopharmaceuticals has gained high interest due to its
great sensitivity, specificity, and lower risk of negative effects to patients. Biopharmaceuticals …

Biotechnological production and practical application of L-asparaginase enzyme

A Vimal, A Kumar - Biotechnology and genetic engineering reviews, 2017 - Taylor & Francis
L-asparaginase is a vital enzyme of medical importance, and renowned as a
chemotherapeutic agent. The relevance of this enzyme is not only limited as an anti-cancer …

Biochemical characterization of extremozyme L-asparaginase from Pseudomonas sp. PCH199 for therapeutics

S Darnal, V Patial, V Kumar, S Kumar, V Kumar… - AMB Express, 2023 - Springer
Abstract L-asparaginase (L-ASNase) from microbial sources is a commercially vital enzyme
to treat acute lymphoblastic leukemia. However, the side effects associated with the …

Exploring current scenario and developments in the field of microbial L-asparaginase production and applications: A review

PG Patel, HZ Panseriya, AK Vala, BP Dave… - Process …, 2022 - Elsevier
L-asparaginase, an amidohydrolase that catalyses break down of L-asparagine into aspartic
acid and ammonia, is one of the most prominent biopharmaceuticals. L-asparaginase (LA) …

Process development for scale-up production of a therapeutic L-asparaginase by Streptomyces brollosae NEAE-115 from shake flasks to bioreactor

NEA El-Naggar, H Moawad, NM El-Shweihy… - Scientific reports, 2019 - nature.com
L-asparaginase is a promising enzyme that has a wide range of significant applications
including cancer therapy and starchy food industries. The statistical design of Plackett …

[HTML][HTML] Response surface methodological optimization of l-asparaginase production from the medicinal plant endophyte Acinetobacter baumannii ZAS1

KN Abhini, AB Rajan, KF Zuhara… - Journal of Genetic …, 2022 - Elsevier
Background This study targets the enhanced production of l-asparaginase, an antitumor
enzyme by Acinetobacter baumannii ZAS1. This organism is an endophyte isolated from the …

l‐asparaginase production and enhancement by Sarocladium strictum: In vitro evaluation of anti‐cancerous properties

A Golbabaie, H Nouri, H Moghimi… - Journal of applied …, 2020 - academic.oup.com
Aims Utilization of l‐asparaginase has been one of the effective strategies for the treatment
of lymphoblastic leukaemia. Since the currently used bacterial l‐asparaginase causes side …

Performance evaluation and yield optimization of L-glutaminase free L-asparaginase from seaweed-associated bacteria

DE Mathew, AK Vala, R Dineshkumar… - Bioresource Technology …, 2023 - Elsevier
Gracilaria dura associated bacterial diversity revealed 75 isolates, which were screened for
L-asparaginase (LA) production. Out of the three positive isolates, upon secondary …

Studies on efficient production of a novel l-asparaginase by a newly isolated Pseudomonas resinovorans IGS-131 and its heterologous expression in Escherichia coli

KN Mihooliya, J Nandal, A Kumari, S Nanda, H Verma… - 3 Biotech, 2020 - Springer
In the current study, the production of novel glutaminase free l-asparaginase from a new
microbial source (Pseudomonas resinovorans IGS-131) is reported. Optimization of l …

In vitro screening and in silico validation revealed key microbes for higher production of significant therapeutic enzyme l-asparaginase

A Vimal, A Kumar - Enzyme and Microbial Technology, 2017 - Elsevier
Abstract l-asparaginase is an enzyme of medical prominence and reputable as a
chemotherapeutic agent. It also has immense potential to cure autoimmune and infectious …