Ca2+-release channels are giant membrane proteins that control the release of Ca2+ from
the endoplasmic and sarcoplasmic reticulum. The two members, ryanodine receptors …

Cellular homeostasis is essential for healthy functioning of cells and tissues as well as
proper organ development and maintenance. A disruption in cellular homeostasis triggers …

The ryanodine receptor (RyR2) has a critical role in controlling Ca2+ release from the
sarcoplasmic reticulum (SR) throughout the cardiac cycle. RyR2 protein has multiple …

Aims Chronic tachypacing is commonly used in animals to induce cardiac dysfunction and to
study mechanisms of heart failure and arrhythmogenesis. Human induced pluripotent stem …

Calcium is the third most abundant metal on earth, and the fundaments of its homeostasis
date back to pre-eukaryotic life forms. In higher organisms, Ca2+ serves as a cofactor for a …

Calsequestrin (CASQ) is the most abundant Ca 2+ binding protein localized in the
sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. The genome of vertebrates …

The present review focusses on the regulation and interplay of cardiac SR Ca2+ handling
proteins involved in SR Ca2+ uptake and release, ie, SERCa2/PLN and RyR2. Both RyR2 …

Calsequestrin is the major Ca 2+ binding protein in the sarcoplasmic reticulum (SR), serves
as the main Ca 2+ storage and buffering protein and is an important regulator of Ca 2+ …

Ryanodine receptor calcium release channels (RyRs) play central roles in controlling
intracellular calcium concentrations in excitable and non-excitable cells. RyRs are located in …

Calsequestrin Type 2 (CASQ2) is a high-capacity, low-affinity, Ca2+-binding protein
expressed in the sarcoplasmic reticulum (SR) of the cardiac myocyte. Mutations in CASQ2 …