Monoclonal antibodies are a growing class of targeted cancer therapeutics, characterized by
exquisite specificity, long serum half-life, high affinity and immune effector functions. In this …

Monoclonal antibodies (mAbs) are a crucial asset for human health and modern medicine,
however, the repeated administration of mAbs can be highly immunogenic. Drug …

Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining
the ionization of a drug in the human body. The Henderson-Hasselbalch equation and pH …

The cellular uptake, intracellular processing, and presentation of foreign antigen are crucial
processes for eliciting an effective adaptive host response to the majority of pathogens. The …

There is currently an unmet need for better biomarkers across the spectrum of renal
diseases. In this paper, we revisit the role of beta-2 microglobulin (β2M) as a biomarker in …

IgG3 comprises only a minor fraction of IgG and has remained relatively understudied until
recent years. Key physiochemical characteristics of IgG3 include an elongated hinge region …

Oral drug administration is one of the most preferred and simplest routes among both
patients and formulation scientists. Nevertheless, orally delivery of some of the most widely …

Eculizumab, a monoclonal antibody (mAb) directed against complement protein C5, is
considered to be the current standard of care for patients with paroxysmal nocturnal …

Serum albumin (SA), the most abundant soluble protein in the body, maintains plasma
oncotic pressure and regulates the distribution of vascular fluid and has a range of other …

Non-natural amino acids are increasingly used as building blocks in the development of
peptide-based drugs as they expand the available chemical space to tailor function, half-life …