Synaptic plasticity forms and functions

JC Magee, C Grienberger - Annual review of neuroscience, 2020 - annualreviews.org
Synaptic plasticity, the activity-dependent change in neuronal connection strength, has long
been considered an important component of learning and memory. Computational and …

Time cells in the hippocampus: a new dimension for mapping memories

H Eichenbaum - Nature Reviews Neuroscience, 2014 - nature.com
Recent studies have revealed the existence of hippocampal neurons that fire at successive
moments in temporally structured experiences. Several studies have shown that such …

Entorhinal cortex directs learning-related changes in CA1 representations

C Grienberger, JC Magee - Nature, 2022 - nature.com
Learning-related changes in brain activity are thought to underlie adaptive behaviours,. For
instance, the learning of a reward site by rodents requires the development of an over …

Complementary learning systems within the hippocampus: a neural network modelling approach to reconciling episodic memory with statistical learning

AC Schapiro, NB Turk-Browne… - … of the Royal …, 2017 - royalsocietypublishing.org
A growing literature suggests that the hippocampus is critical for the rapid extraction of
regularities from the environment. Although this fits with the known role of the hippocampus …

The hippocampal CA2 region is essential for social memory

FL Hitti, SA Siegelbaum - Nature, 2014 - nature.com
The hippocampus is critical for encoding declarative memory, our repository of knowledge of
who, what, where and when. Mnemonic information is processed in the hippocampus …

Conjunctive input processing drives feature selectivity in hippocampal CA1 neurons

KC Bittner, C Grienberger, SP Vaidya, AD Milstein… - Nature …, 2015 - nature.com
Feature-selective firing allows networks to produce representations of the external and
internal environments. Despite its importance, the mechanisms generating neuronal feature …

A hippocampal circuit linking dorsal CA2 to ventral CA1 critical for social memory dynamics

T Meira, F Leroy, EW Buss, A Oliva, J Park… - Nature …, 2018 - nature.com
Recent results suggest that social memory requires the dorsal hippocampal CA2 region as
well as a subset of ventral CA1 neurons. However, it is unclear whether dorsal CA2 and …

Assessing spatial learning and memory in rodents

CV Vorhees, MT Williams - ILAR journal, 2014 - academic.oup.com
Maneuvering safely through the environment is central to survival of almost all species. The
ability to do this depends on learning and remembering locations. This capacity is encoded …

What is memory? The present state of the engram

M Poo, M Pignatelli, TJ Ryan, S Tonegawa… - BMC biology, 2016 - Springer
The mechanism of memory remains one of the great unsolved problems of biology.
Grappling with the question more than a hundred years ago, the German zoologist Richard …

Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits

K Kohara, M Pignatelli, AJ Rivest, HY Jung… - Nature …, 2014 - nature.com
The formation and recall of episodic memory requires precise information processing by the
entorhinal-hippocampal network. For several decades, the trisynaptic circuit entorhinal …