BACKGROUND Chromosomal mosaicism can be detected in different stages of early life: in
cleavage stage embryos, in blastocysts and biopsied cells from blastocysts during …

BACKGROUND Infertility and pregnancy loss are longstanding problems. Successful
fertilization and high-quality embryos are prerequisites for an ongoing pregnancy. Studies …

Starting from the zygote, all cells in the human body continuously acquire mutations.
Mutations shared between different cells imply a common progenitor and are thus naturally …

Embryo implantation in humans is interstitial, meaning the entire conceptus embeds in the
endometrium before the placental trophoblast invades beyond the uterine mucosa into the …

Human preimplantation development involves extensive remodeling of RNA expression and
splicing. However, its transcriptome has been compiled using short-read sequencing data …

Aneuploidy, a deviation from the normal chromosome copy number, is common in human
embryos and is considered a primary cause of implantation failure and early pregnancy loss …

Compared to most mammals, human pregnancy is unusual in that it involves chromosomally
diverse embryos, cyclical breakdown and regeneration of the uterine mucosa, and intimate …

Single-cell open chromatin profiling via scATAC-seq has become a mainstream
measurement of open chromatin in single-cells. Here we present epiAneufinder, an …

STUDY QUESTION Are chromosome abnormalities detected at Day 3 post-fertilization
predominantly retained in structures of the blastocyst other than the inner cell mass (ICM) …

STUDY QUESTION What are the outcomes for patients who choose to move embryos
diagnosed as abnormal by preimplantation genetic testing for aneuploidy (PGT-A) to a new …