Leishmaniasis is a neglected tropical disease that affects about 350 million individuals
worldwide. The protozoan parasite has a relatively simple life cycle with two principal …

The leishmaniases represent a public health problem in under-developed countries and are
considered a neglected disease by the World Health Organization (WHO). They are cuased …

l-Arginine is one of the precursor amino acids of polyamine biosynthesis in most living
organisms including Leishmania parasites. l-Arginine is enzymatically hydrolyzed by …

Nitric oxide (NO) represents a valuable target to design antitrypanosomal agents by its high
toxicity against trypanosomatids and minimal side effects on host macrophages. The …

The fact that drugs currently used in the treatment of Leishmania are highly toxic and
associated with acquired resistance has promoted the search for new therapies for treating …

We sought to identify a potent and selective antitrypanosomal agent through modulation of
the mechanism of action of a 2-arylquinazoline scaffold as an antitrypanosomal agent via …

Although nitric oxide (NO) is a bactericidal component of the macrophage's innate response
to intracellular infections such as tuberculosis (TB), prolonged inhalation of NO gas has little …

Parasites of the genus Leishmania are capable of inhibiting effector functions of
macrophages. These parasites have developed the adaptive ability to escape host …

Objectives This study was designed to verify the cytotoxic activity of S-nitrosoglutathione
(GSNO) against intracellular Leishmania amastigotes and to test its efficacy as a topical …

Non-pathogenic mycobacteria such us Mycobacterium smegmatis reside in macrophages
within phagosomes that fuse with late endocytic/lysosomal compartments. This sequential …