Although the treatment of myocardial infarction (MI) has improved considerably, it is still a
worldwide disease with high morbidity and high mortality. Whilst there is still a long way to …

Abstract Sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent deacetylase,
epigenetically regulates various cell metabolisms, including inflammation, tumorigenesis …

Background Exosomes are considered a substitute for stem cell-based therapy for
myocardial infarction (MI). FNDC5, a transmembrane protein located in the cytoplasm, plays …

Osteoporosis is a highly prevalent disorder characterized by the loss of bone mass and
microarchitecture deterioration of bone tissue, attributed to various factors, including …

Inositol pyrophosphates (PP-IPs) such as 5-diphosphoinositol pentakisphosphate (5-IP7)
are inositol metabolites containing high-energy phosphoanhydride bonds. Biosynthesis of …

Acute lung injury (ALI) accompanied with systemic inflammatory response is an important
complication after cardiopulmonary bypass (CPB). Pyroptosis, which is induced by the …

Background Ultrasound-targeted microbubble destruction (UTMD) has emerged as a
promising strategy for the targeted delivery of bone marrow mesenchymal stem cells (MSCs) …

High glucose (HG)‐induced cardiomyocytes (CMs) injury is a leading cause of diabetic
cardiomyopathy with little treatment options. Irisin, a new myokine, which is cleaved from its …

Water-soluble myo-inositol phosphates have long been characterized as second
messengers. The signaling properties of these compounds are determined by the number …

Background The beneficial functions of bone marrow mesenchymal stem cells (BM-MSCs)
decline with decreased cell survival, limiting their therapeutic efficacy for myocardial …