Ethnopharmacological relevance Aconitine, a C 19-norditerpenoid alkaloid, derives from
many medicinal plants such as Aconitum carmichaelii Debx.(Chinese: 乌头), Aconitum …

Aconitine is a diterpenoid alkaloid, which mainly exists in the plants of Aconitum. In the last
decade, a plethora of studies on the pharmacological activities of aconitine has been …

The ubiquity, structural variation, and functional diversity of iron-sulfur (Fe-S) clusters in
biological environments has long fascinated scientists. In nature, Fe-S clusters form a variety …

Fe‐S centers exhibit strong electronic plasticity, which is of importance for insuring fine
redox tuning of protein biological properties. In accordance, Fe‐S clusters are also highly …

A combined in silico method was developed to predict potential protein targets that are
involved in cardiotoxicity induced by aconitine alkaloids and to study the quantitative …

Aconitine is a plant toxin derived from aconitum genus and well known for its neurological
and vascular toxicity. However, the mechanism of toxicity on the growth and apoptosis of the …

Hepatocellular carcinoma (HCC) is the primary liver cancer that occurs with a high incidence
in Asia. Owing to the poor prognosis of the disease, the mortality rate remains high, making …

Background: The efficacy of antimetabolic therapy of malignant neoplasms could not be
explained solely by the direct mechanisms of action of such energy metabolism inhibitors as …

Combined chronic treatment of Ehrlich solid carcinoma (EC) with an NOS inhibitor 1-
isobutanoyl-2-isopropylisothiourea hydrobromide (T1023) and a PDK1 inhibitor …

目的研究乌头碱对食管癌EC-1 细胞增殖, 侵袭和凋亡的影响. 方法CCK8 法及克隆形成抑制实验
检测乌头碱对食管癌EC-1 细胞的生长抑制作用; 采用Hoechst 33258 染色检测乌头碱对EC-1 …