Eph receptor Tyr kinases and their membrane-tethered ligands, the ephrins, elicit short-
distance cell–cell signalling and thus regulate many developmental processes at the …

The Eph receptors are the largest of the RTK families. Like other RTKs, they transduce
signals from the cell exterior to the interior through ligand-induced activation of their kinase …

The establishment of precise neuronal cell morphology provides the foundation for all
aspects of neurobiology. During development, axons emerge from cell bodies after an initial …

Collective cell migration occurs in a range of contexts: cancer cells frequently invade in
cohorts while retaining cell–cell junctions. Here we show that collective invasion by cancer …

Eph receptors, the largest subfamily of receptor tyrosine kinases, are linked with proliferative
disease, such as cancer, as a result of their deregulated expression or mutation. Unlike …

Ephrin ligands and their cognate Eph receptors guide axons during neural development and
regulate synapse formation and neuronal plasticity in the adult. Because ephrins are …

The development, homeostasis, and regeneration of complex organ systems require
extensive cell–cell communication to ensure that different cells proliferate, migrate …

The diversity of dendritic patterns is one of the fundamental characteristics of neurons and is
in part regulated by transcriptional programs initiated by electrical activity. We show that …

Ephrins are cell-surface tethered guidance cues that bind to Eph receptor tyrosine kinases in
trans on opposing cells. In the developing nervous system, the Eph–ephrin signaling system …

Purpose The management of epilepsy in children is particularly challenging when seizures
are resistant to antiepileptic medications, or undergo many changes in seizure type over …