Histone deacetylases (HDACs) are enzymes that play a key role in the epigenetic regulation
of gene expression by remodeling chromatin. Inhibition of HDACs is a prospective …

Histone deacetylases (HDACs) are enzymes involved in the remodelling of chromatin, and
have a key role in the epigenetic regulation of gene expression. In addition, the activity of …

The balance of histone acetylation and deacetylation is an epigenetic layer with a critical
role in the regulation of gene expression. Histone acetylation induced by histone acetyl …

Multiple myeloma (MM) is a B cell malignancy resulting in osteolytic lesions and fractures. In
the disease state, bone healing is limited owing to increased osteoclastic and decreased …

High activity of histone deacetylases (HDACs) causes epigenetic alterations associated with
malignant cell behaviour. Consequently, HDAC inhibitors have entered late-phase clinical …

Epigenetics is the study of heritable alterations in gene expression that are not accompanied
by the corresponding change in DNA sequence. Three interlinked epigenetic processes …

Dysregulation of histone deacetylases (HDACs) is closely related to tumor development and
progression. As promising anticancer targets, HDACs have gained a great deal of research …

The histone deacetylase (HDAC) inhibitors are emerging as a highly useful class of
anticancer agents that inhibit the enzyme HDAC involved in the deacetylation of histone and …

Histone deacetylases (HDACs) can regulate expression of tumor suppressor genes and
activities of transcriptional factors involved in both cancer initiation and progression through …

Histone deacetylases (HDACs) play an important role in the epigenetic regulation of gene
expression by catalyzing the removal of acetyl groups, stimulating chromatin condensation …