Tyrosine conjugation methods for protein labelling

D Alvarez Dorta, D Deniaud, M Mével… - … –A European Journal, 2020 - Wiley Online Library
Over the last two decades, the development of chemical biology and the need for more
defined protein conjugates have fostered active research on new bioconjugation …

Research progress on chemical modifications of tyrosine residues in peptides and proteins

W Zeng, J Xue, H Geng, X Liu, J Yang… - Biotechnology and …, 2024 - Wiley Online Library
The chemical modifications (CMs) of protein is an important technique in chemical biology,
protein‐based therapy, and material science. In recent years, there has been rapid …

A chemoselective rapid azo-coupling reaction (CRACR) for unclickable bioconjugation

PS Addy, SB Erickson, JS Italia… - Journal of the American …, 2017 - ACS Publications
Chemoselective modification of complex biomolecules has become a cornerstone of
chemical biology. Despite the exciting developments of the past two decades, the demand …

Modifications of amino acids using arenediazonium salts

S Sengupta, S Chandrasekaran - Organic & Biomolecular Chemistry, 2019 - pubs.rsc.org
Aryl transfer reactions from arenediazonium salts have started to make their impact in
chemical biology with initial forays in the arena of arylative modifications and bio …

Protein modification via mild photochemical isomerization of triazenes to release aryl diazonium ions

GJ Davis, JA Townsend, MG Morrow… - Bioconjugate …, 2021 - ACS Publications
This work describes the development of phenyl diazenyl piperidine triazene derivatives that
can be activated to release aryl diazonium ions for labeling of proteins using light. These …

Virus-based supramolecular structure and materials: Concept and prospects

C Hou, H Xu, X Jiang, Y Li, S Deng… - ACS Applied Bio …, 2021 - ACS Publications
Rodlike and spherelike viruses are various monodisperse nanoparticles that can display
small molecules or polymers with unique distribution following chemical modifications …

Copper-free click enabled triazabutadiene for bioorthogonal protein functionalization

AN Wijetunge, GJ Davis, M Shadmehr… - Bioconjugate …, 2021 - ACS Publications
Aryl diazonium ions have long been used in bioconjugation due to their reactivity toward
electron-rich aryl residues, such as tyrosine. However, their utility in biological systems has …

Selective Triazenation Reaction (STaR) of secondary amines for tagging monomethyl lysine post‐translational modifications

O Nwajiobi, S Mahesh, X Streety, M Raj - Angewandte Chemie, 2021 - Wiley Online Library
Lysine monomethylation (Kme) is an impactful post‐translational modification (PTM)
responsible for regulating biological processes and implicated in diseases, thus there is …

Site-directed chemically-modified magnetic enzymes: fabrication, improvements, biotechnological applications and future prospects

AM Shemsi, FA Khanday, A Qurashi, A Khalil… - Biotechnology …, 2019 - Elsevier
Numerous enzymes of biotechnological importance have been immobilized on magnetic
nanoparticles (MNP) via random multipoint attachment, resulting in a heterogeneous protein …

A Novel Bifunctional Chelating Agent for Tyrosine-Specific Radiolabeling of Peptides and Proteins

D Nakano, H Watanabe, S Kosuke… - Bioconjugate Chemistry, 2024 - ACS Publications
Site-specific radiolabeling is utilized for the development of antibody-or peptide-based
radiotheranostic agents. Although tyrosine can be exploited as one of the target residues for …