Metastasis formation is the major cause of death in most patients with cancer. Despite
extensive research, targeting metastatic seeding and colonization is still an unresolved …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

Non-covalent complexes of glycolytic enzymes, called metabolons, were postulated in the
1970s, but the concept has been controversial. Here we show that a c-Myc-responsive long …

Metabolism encompasses the biochemical processes that allow healthy cells to keep
energy, redox balance and building blocks required for cell development, survival, and …

Cancer cells rewire their metabolism to survive during cancer progression. In this context,
tumour metabolic heterogeneity arises and develops in response to diverse environmental …

Abstract Background Live kinase B1 (LKB1) is a tumor suppressor, which is mutated in
Peutz-Jeghers syndrome (PJS) and in a variety of cancers. Lkb1 encodes serine-threonine …

Phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme of serine
synthesis, is frequently overexpressed in human cancer. PHGDH overexpression activates …

Guanine O 6-alkylating agents are widely used as first-line chemotherapeutic drugs due to
their ability to induce cytotoxic DNA damage. However, a major hurdle in their effectiveness …

Osteosarcoma is the most common pediatric and adult primary malignant bone cancer.
Curative regimens target the folate pathway, downstream of serine metabolism, with high …

Serine is a non-essential amino acid that is critical for tumour proliferation and depletion of
circulating serine results in reduced tumour growth and increased survival in various cancer …