Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination
99% of administered nanoparticles will accumulate and sequester in the liver after
administration into the body. This results in reduced delivery to the targeted diseased tissue …
administration into the body. This results in reduced delivery to the targeted diseased tissue …
Extracellular vesicles as drug delivery systems: lessons from the liposome field
R van der Meel, MHAM Fens, P Vader… - Journal of controlled …, 2014 - Elsevier
Extracellular vesicles (EVs) are membrane-derived particles surrounded by a (phospho)
lipid bilayer that are released by cells in the human body. In addition to direct cell-to-cell …
lipid bilayer that are released by cells in the human body. In addition to direct cell-to-cell …
Long-circulating and target-specific nanoparticles: theory to practice
The rapid recognition of intravenously injected colloidal carriers, such as liposomes and
polymeric nanospheres from the blood by Kupffer cells, has initiated a surge of development …
polymeric nanospheres from the blood by Kupffer cells, has initiated a surge of development …
Lipid-based nanoparticle technologies for liver targeting
Liver diseases such as hepatitis, cirrhosis, and hepatocellular carcinoma are global health
problems accounting for approximately 800 million cases and over 2 million deaths per year …
problems accounting for approximately 800 million cases and over 2 million deaths per year …
Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review
F Braet, E Wisse - Comparative hepatology, 2002 - Springer
This review provides a detailed overview of the current state of knowledge about the
ultrastructure and dynamics of liver sinusoidal endothelial fenestrae. Various aspects of liver …
ultrastructure and dynamics of liver sinusoidal endothelial fenestrae. Various aspects of liver …
Optimization of the preparation process for human serum albumin (HSA) nanoparticles
K Langer, S Balthasar, V Vogel, N Dinauer… - International journal of …, 2003 - Elsevier
Nanoparticles prepared by desolvation and subsequent crosslinking of human serum
albumin (HSA) represent promising carriers for drug delivery. Particle size is a crucial …
albumin (HSA) represent promising carriers for drug delivery. Particle size is a crucial …
Vasculature organotropism in drug delivery
Over the past decades, there has been an exponential increase in the development of
preclinical and clinical nanodelivery systems, and recently, an accelerating demand to …
preclinical and clinical nanodelivery systems, and recently, an accelerating demand to …
Applications of nanobiomaterials in the therapy and imaging of acute liver failure
Highlights This review focuses on the therapeutic mechanisms, targeting strategies of
various nanomaterials in acute liver failure, and recent advances of diverse nanomaterials …
various nanomaterials in acute liver failure, and recent advances of diverse nanomaterials …
Advanced nanotheranostics of CRISPR/Cas for viral hepatitis and hepatocellular carcinoma
Liver disease, particularly viral hepatitis and hepatocellular carcinoma (HCC), is a global
healthcare burden and leads to more than 2 million deaths per year worldwide. Despite …
healthcare burden and leads to more than 2 million deaths per year worldwide. Despite …
Long‐term maintenance of a microfluidic 3D human liver sinusoid
The development of long‐term human organotypic liver‐on‐a‐chip models for successful
prediction of toxic response is one of the most important and urgent goals of the …
prediction of toxic response is one of the most important and urgent goals of the …