Glutathione in the human brain: Review of its roles and measurement by magnetic resonance spectroscopy
CD Rae, SR Williams - Analytical biochemistry, 2017 - Elsevier
We review the transport, synthesis and catabolism of glutathione in the brain as well as its
compartmentation and biochemistry in different brain cells. The major reactions involving …
compartmentation and biochemistry in different brain cells. The major reactions involving …
Molecular mechanisms of bipolar disorder: progress made and future challenges
Bipolar disorder (BD) is a chronic and progressive psychiatric illness characterized by mood
oscillations, with episodes of mania and depression. The impact of BD on patients can be …
oscillations, with episodes of mania and depression. The impact of BD on patients can be …
Right care, first time: a highly personalised and measurement‐based care model to manage youth mental health
Mood and psychotic syndromes most often emerge during adolescence and young
adulthood, a period characterised by major physical and social change. Consequently, the …
adulthood, a period characterised by major physical and social change. Consequently, the …
In vivo brain GSH: MRS methods and clinical applications
F Bottino, M Lucignani, A Napolitano, F Dellepiane… - Antioxidants, 2021 - mdpi.com
Glutathione (GSH) is an important antioxidant implicated in several physiological functions,
including the oxidation− reduction reaction balance and brain antioxidant defense against …
including the oxidation− reduction reaction balance and brain antioxidant defense against …
Is there a glutathione centered redox dysregulation subtype of schizophrenia?
Schizophrenia continues to be an illness with poor outcome. Most mechanistic changes
occur many years before the first episode of schizophrenia; these are not reversible after the …
occur many years before the first episode of schizophrenia; these are not reversible after the …
[HTML][HTML] Mitochondria dysfunction and bipolar disorder: from pathology to therapy
Bipolar disorder (BD) is one of the major psychiatric diseases in which the impairment of
mitochondrial functions has been closely connected or associated with the disease …
mitochondrial functions has been closely connected or associated with the disease …
The underlying neurobiology of key functional domains in young people with mood and anxiety disorders: a systematic review
Background Mood and anxiety disorders are leading causes of disability and mortality, due
largely to their onset during adolescence and young adulthood and broader impact on …
largely to their onset during adolescence and young adulthood and broader impact on …
Dorsal Anterior Cingulate Lactate and Glutathione Levels in Euthymic Bipolar I Disorder: 1H-MRS Study
MG Soeiro-de-Souza, BF Pastorello… - International Journal …, 2016 - academic.oup.com
Objective: Oxidative stress and mitochondrial dysfunction are 2 closely integrated processes
implicated in the physiopathology of bipolar disorder. Advanced proton magnetic resonance …
implicated in the physiopathology of bipolar disorder. Advanced proton magnetic resonance …
Beyond the therapeutic shackles of the monoamines: new mechanisms in bipolar disorder biology
Multiple novel biological mechanisms putatively involved in the etiology of bipolar disorders
are being explored. These include oxidative stress, altered glutamatergic …
are being explored. These include oxidative stress, altered glutamatergic …
In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders
Fronto-limbic connectivity is compromised in mood disorders, as reflected by impairments in
white matter (WM) integrity revealed by diffusion tensor imaging. Although the underlying …
white matter (WM) integrity revealed by diffusion tensor imaging. Although the underlying …