[HTML][HTML] Antivirals for COVID-19: a critical review
No specific drugs have been approved for coronavirus disease 2019 (COVID-19) to date as
the development of antivirals usually requires time. Therefore, assessment and use of …
the development of antivirals usually requires time. Therefore, assessment and use of …
The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives
L Wanka, K Iqbal, PR Schreiner - Chemical reviews, 2013 - ACS Publications
A simple, primary amine bearing a C10H15 alkyl residue was found to display potent anti-
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
Influenza A properties in 1964. 1 Soon thereafter, antiviral activity of this amine was found …
A systematic review of the global intervention for SARS-CoV-2 combating: from drugs repurposing to molnupiravir approval
NA Ashour, A Abo Elmaaty, AA Sarhan… - Drug design …, 2023 - Taylor & Francis
The rising outbreak of SARS-CoV-2 continues to unfold all over the world. The development
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …
of novel effective antiviral drugs to fight against SARS-CoV-2 is a time cost. As a result, some …
Viroporins and inflammasomes: a key to understand virus-induced inflammation
Viroporins are virus encoded proteins that alter membrane permeability and can trigger
subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a …
subsequent cellular signals. Oligomerization of viroporin subunits results in formation of a …
[HTML][HTML] Viroporins: structure and biological functions
JL Nieva, V Madan, L Carrasco - Nature Reviews Microbiology, 2012 - nature.com
Viroporins are small, hydrophobic proteins that are encoded by a wide range of clinically
relevant animal viruses. When these proteins oligomerize in host cell membranes, they form …
relevant animal viruses. When these proteins oligomerize in host cell membranes, they form …
The ins and outs of hepatitis C virus entry and assembly
BD Lindenbach, CM Rice - Nature Reviews Microbiology, 2013 - nature.com
Hepatitis C virus, a major human pathogen, produces infectious virus particles with several
unique features, such as an ability to interact with serum lipoproteins, a dizzyingly …
unique features, such as an ability to interact with serum lipoproteins, a dizzyingly …
Replication of hepatitis C virus
D Moradpour, F Penin, CM Rice - Nature reviews microbiology, 2007 - nature.com
Exciting progress has recently been made in understanding the replication of hepatitis C
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …
virus, a major cause of chronic hepatitis, liver cirrhosis and hepatocellular carcinoma …
Endoplasmic-reticulum calcium depletion and disease
D Mekahli, G Bultynck, JB Parys… - Cold Spring …, 2011 - cshperspectives.cshlp.org
The endoplasmic reticulum (ER) as an intracellular Ca2+ store not only sets up cytosolic
Ca2+ signals, but, among other functions, also assembles and folds newly synthesized …
Ca2+ signals, but, among other functions, also assembles and folds newly synthesized …
Structure and mechanism of the M2 proton channel of influenza A virus
JR Schnell, JJ Chou - Nature, 2008 - nature.com
The integral membrane protein M2 of influenza virus forms pH-gated proton channels in the
viral lipid envelope. The low pH of an endosome activates the M2 channel before …
viral lipid envelope. The low pH of an endosome activates the M2 channel before …
The molecular biology of pestiviruses
N Tautz, BA Tews, G Meyers - Advances in virus research, 2015 - Elsevier
Pestiviruses are among the economically most important pathogens of livestock. The biology
of these viruses is characterized by unique and interesting features that are both crucial for …
of these viruses is characterized by unique and interesting features that are both crucial for …