A review on ferulic acid and analogs based scaffolds for the management of Alzheimer's disease
Alzheimer's disease (AD) is an age-related multifactorial neurodegenerative disorder
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …
characterized by severe central cholinergic neuronal loss, gradually contributing to cognitive …
A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer's disease
X Zhang, X He, Q Chen, J Lu, S Rapposelli… - Bioorganic & medicinal …, 2018 - Elsevier
Abstract Alzheimer's disease (AD), a complex chronic progressive central nervous system
degenerative disease and a public health problem of the world, often characters cognitive …
degenerative disease and a public health problem of the world, often characters cognitive …
Novel thiophene Chalcones-Coumarin as acetylcholinesterase inhibitors: Design, synthesis, biological evaluation, molecular docking, ADMET prediction and …
A series of around eight novel chalcone based coumarin derivatives (23a-h) was designed,
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
subjected to in-silico ADMET prediction, synthesized, characterized by IR, NMR, Mass …
Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation
C Tian, X Qiang, Q Song, Z Cao, C Ye, Y He, Y Deng… - Bioorganic …, 2020 - Elsevier
The complex pathogenesis of Alzheimer's disease (AD) calls for multitarget approach for
disease management. Herein, a series of novel flurbiprofen-chalcone hybrid Mannich base …
disease management. Herein, a series of novel flurbiprofen-chalcone hybrid Mannich base …
Design, synthesis, anti-acetylcholinesterase evaluation and molecular modelling studies of novel coumarin-chalcone hybrids
The major enzyme responsible for the hydrolytic breakdown of the neurotransmitter
acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors …
acetylcholine (ACh) is acetylcholinesterase (AChE). Acetylcholinesterase inhibitors …
Synthesis and antiviral activity of novel myricetin derivatives containing ferulic acid amide scaffolds
X Tang, C Zhang, M Chen, Y Xue, T Liu… - New Journal of …, 2020 - pubs.rsc.org
A variety of myricetin derivatives bearing ferulic acid amide scaffolds were designed and
synthesized. The structures of all title compounds were determined by 1H NMR, 13C NMR …
synthesized. The structures of all title compounds were determined by 1H NMR, 13C NMR …
Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease
Z Sang, K Wang, P Bai, A Wu, J Shi, W Liu… - European Journal of …, 2020 - Elsevier
A novel series of O-carbamoyl ferulamide derivatives were designed by multitarget-directed
ligands (MTDLs) strategy, the derivatives were synthesized and evaluated to treat …
ligands (MTDLs) strategy, the derivatives were synthesized and evaluated to treat …
Discovery of δ-sultone-fused pyrazoles for treating Alzheimer's disease: Design, synthesis, biological evaluation and SAR studies
Y Xu, Z Zhang, X Jiang, X Chen, Z Wang… - European Journal of …, 2019 - Elsevier
A class of novel δ-sulfonolactone-fused pyrazole scaffold was prepared via sulfur (VI)
fluoride exchange (SuFEx) chemistry using aryl sulfonyl fluorides and pyrazolones. Enzyme …
fluoride exchange (SuFEx) chemistry using aryl sulfonyl fluorides and pyrazolones. Enzyme …
Ferulic acid delayed amyloid β-induced pathological symptoms by autophagy pathway via a fasting-like effect in Caenorhabditis elegans
N Wang, Y Zhou, L Zhao, C Wang, W Ma, G Ge… - Food and Chemical …, 2020 - Elsevier
The amyloid β (Aβ) generation or aggregation plays a crucial role in Alzheimer's disease
(AD). Autophagy agonists, which function as the clearance of Aβ, could be the potential drug …
(AD). Autophagy agonists, which function as the clearance of Aβ, could be the potential drug …
[HTML][HTML] Structural modifications on chalcone framework for developing new class of cholinesterase inhibitors
G George, VP Koyiparambath, S Sukumaran… - International Journal of …, 2022 - mdpi.com
Due to the multifaceted pharmacological activities of chalcones, these scaffolds have been
considered one of the most privileged frameworks in the drug discovery process …
considered one of the most privileged frameworks in the drug discovery process …