The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …

Bile acids are the end products of cholesterol catabolism. Hepatic bile acid synthesis
accounts for a major fraction of daily cholesterol turnover in humans. Biliary secretion of bile …

Bile acids are important physiological agents for intestinal nutrient absorption and biliary
secretion of lipids, toxic metabolites, and xenobiotics. Bile acids also are signaling …

Objective The development of these guidelines is mandated by the American Association of
Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology …

Over the past decade, it has become apparent that bile acids are involved in a host of
activities beyond their classic functions in bile formation and fat absorption. The identification …

Nuclear receptors are integrators of hormonal and nutritional signals, mediating changes to
metabolic pathways within the body. Given that modulation of lipid and glucose metabolism …

Metformin is one of the most widely prescribed hypoglycemic drugs and has the potential to
treat many diseases. More and more evidence shows that metformin can regulate the …

Introduction: Additional oral antidiabetic agents to metformin, sulfonylureas (SU) and
thiazolidinediones (TZD) are approved for the treatment of type 2 diabetes. Areas covered …

Dyslipidemia is one of the key risk factors for cardiovascular disease (CVD) in diabetes
mellitus. Despite the mounting clinical trial data, the management of dyslipidemia other than …

Gastric bypass leads to the remission of type 2 diabetes independently of weight loss. Our
hypothesis is that changes in bile flow due to the altered anatomy may partly explain the …