Mechanisms in photodynamic therapy: part one—photosensitizers, photochemistry and cellular localization

AP Castano, TN Demidova, MR Hamblin - … and photodynamic therapy, 2004 - Elsevier
The use of non-toxic dyes or photosensitizers (PS) in combination with harmless visible light
that is known as photodynamic therapy (PDT) has been known for over a hundred years, but …

[HTML][HTML] Direct and indirect effects of UV radiation on DNA and its components

JL Ravanat, T Douki, J Cadet - Journal of Photochemistry and Photobiology …, 2001 - Elsevier
In this survey, emphasis was placed on the main photoreactions of nucleic acid components,
involving both direct and indirect effects. The main UVB-and UVA-induced DNA …

Reactions of oxyl radicals with DNA

AP Breen, JA Murphy - Free radical biology and medicine, 1995 - Elsevier
The importance of radical-induced damage to DNA is apparent from the ever-increasing
number of publications in this area. This review focuses on the damage caused to DNA by …

Benzophenone photosensitized DNA damage

MC Cuquerella, V Lhiaubet-Vallet, J Cadet… - Accounts of chemical …, 2012 - ACS Publications
Although the carcinogenic potential of ultraviolet radiation is well-known, UV light may
interact with DNA by direct absorption or through photosensitization by endogenous or …

Oxidative damage to DNA: formation, measurement, and biological significance

J Cadet, M Berger, T Douki, JL Ravanat - … of Reactive Oxygens, NO, CO, II, 2005 - Springer
Deoxyribonucleic acid (DNA) appears to be a critical cellular target for the biological effects
(cellular lethality, mutagenesis, carcinogenesis, and ageing) of oxidation processes …

X-ray activated nanoplatforms for deep tissue photodynamic therapy

JS Souris, L Leoni, HJ Zhang, A Pan, E Tanios… - Nanomaterials, 2023 - mdpi.com
Photodynamic therapy (PDT), the use of light to excite photosensitive molecules whose
electronic relaxation drives the production of highly cytotoxic reactive oxygen species (ROS) …

Reaction of singlet oxygen with 2'-deoxyguanosine and DNA. Isolation and characterization of the main oxidation products

JL Ravanat, J Cadet - Chemical research in toxicology, 1995 - ACS Publications
The genotoxicity and the mutagenicity of 102, as the result of DNA oxidation, have been
determined (for recent reviews see refs 1—3). A major source of 1Ü2 is photo-sensitization …

Guanine oxidation: One‐and two‐electron reactions

G Pratviel, B Meunier - Chemistry–A European Journal, 2006 - Wiley Online Library
Guanine bases in DNA are the most sensitive to oxidation. A lot of effort has been devoted to
the understanding of the chemical modifications of guanine under different oxidizing …

UV and ionizing radiations induced DNA damage, differences and similarities

JL Ravanat, T Douki - Radiation Physics and Chemistry, 2016 - Elsevier
Both UV and ionizing radiations damage DNA. Two main mechanisms, so-called direct and
indirect pathways, are involved in the degradation of DNA induced by ionizing radiations …

Characterization of lysine− guanine cross-links upon one-electron oxidation of a guanine-containing oligonucleotide in the presence of a trilysine peptide

S Perrier, J Hau, D Gasparutto, J Cadet… - Journal of the …, 2006 - ACS Publications
Formation of DNA− protein cross-links involving the initial formation of a guanine radical
cation was investigated. For this purpose, riboflavin-mediated photosensitization of a TGT …