Bile acid metabolism and signaling, the microbiota, and metabolic disease

J Cai, B Rimal, C Jiang, JYL Chiang… - Pharmacology & …, 2022 - Elsevier
The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …

Vitamin E (alpha-tocopherol) metabolism and nutrition in chronic kidney disease

F Galli, M Bonomini, D Bartolini, L Zatini, G Reboldi… - Antioxidants, 2022 - mdpi.com
Vitamin E (alpha-tocopherol) is an essential micronutrient and fat-soluble antioxidant with
proposed role in protecting tissues from uncontrolled lipid peroxidation. This vitamin has …

Dietary phytochemicals as modulators of human pregnane X receptor

J Zhang, P Pavek, R Kamaraj, L Ren… - CritiCal reviews in Food …, 2023 - Taylor & Francis
As a promiscuous xenobiotic sensor, pregnane X receptor (PXR) plays a crucial role in drug
metabolism. Since dietary phytochemicals exhibit the potential to modulate human PXR, this …

Metabolism of natural forms of vitamin E and biological actions of vitamin E metabolites

Q Jiang - Free Radical Biology and Medicine, 2022 - Elsevier
Natural forms of vitamin E comprise four tocopherols and four tocotrienols. During the last
twenty years, there have been breakthroughs in our understanding of vitamin E metabolism …

Vitamin E and metabolic health: Relevance of interactions with other micronutrients

S Liao, SO Omage, L Börmel, S Kluge, M Schubert… - Antioxidants, 2022 - mdpi.com
A hundred years have passed since vitamin E was identified as an essential micronutrient
for mammals. Since then, many biological functions of vitamin E have been unraveled in …

Different Roles of Tocopherols and Tocotrienols in Chemoprevention and Treatment of Prostate Cancer

Q Jiang - Advances in Nutrition, 2024 - pmc.ncbi.nlm.nih.gov
The vitamin E family contains α-tocopherol (αT), βT, γT, and δT and α-tocotrienol (TE), βTE,
γTE, and δTE. Research has revealed distinct roles of these vitamin E forms in prostate …

Metabolic and functional interplay between gut microbiota and fat-soluble vitamins

V Stacchiotti, S Rezzi, M Eggersdorfer… - Critical reviews in food …, 2021 - Taylor & Francis
Gut microbiota is a complex ecosystem seen as an extension of human genome. It
represents a major metabolic interface of interaction with food components and xenobiotics …

Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant

J Tauchen, A Frankova, A Manourova, I Valterova… - Phytochemistry …, 2023 - Springer
Abstract Garcinia kola Heckel (Clusiaceae) is a tree indigenous to West and Central Africa.
All plant parts, but especially the seeds, are of value in local folklore medicine. Garcinia kola …

Alpha-tocopherol metabolites (the vitamin E metabolome) and their interindividual variability during supplementation

D Bartolini, R Marinelli, D Giusepponi, R Galarini… - Antioxidants, 2021 - mdpi.com
The metabolism of α-tocopherol (α-TOH, vitamin E) shows marked interindividual variability,
which may influence the response to nutritional and therapeutic interventions with this …

Endogenous vitamin E metabolites mediate allosteric PPARγ activation with unprecedented co-regulatory interactions

S Willems, L Gellrich, A Chaikuad, S Kluge, O Werz… - Cell Chemical …, 2021 - cell.com
Vitamin E exhibits pharmacological effects beyond established antioxidant activity
suggesting involvement of unidentified mechanisms. Here, we characterize endogenously …