Over the past decade there has been an increasing reliance on strong opioids to treat acute
and chronic pain, which has been associated with a rising epidemic of prescription opioid …

Background Acute postoperative pain is common. Nearly 20 per cent of patients experience
severe pain in the first 24 h after surgery, a figure that has remained largely unchanged in …

Introduction Worldwide, more than 20 million patients undergo groin hernia repair annually.
The many different approaches, treatment indications and a significant array of techniques …

Background Widely used for acute pain management, the clinical benefit from perioperative
use of gabapentinoids is uncertain. The aim of this systematic review was to assess the …

Background Over the past 2 decades, the use of intravenous ketamine infusions as a
treatment for chronic pain has increased dramatically, with wide variation in patient …

Surveys and registries are needed to verify that real-life daily practice is in keeping with what
is recommended in the guidelines, thus completing the loop between clinical research …

Injury to or disease of the nervous system can invoke chronic and sometimes intractable
neuropathic pain. Many parallel, interdependent, and time-dependent processes, including …

Objectives: This review presents and discusses basic science findings and scientific
evidence generated within the last 2 decades in the field of acute postoperative pain …

Postoperative pain has been poorly managed for decades. Recent surveys from USA and
Europe do not show any major improvement. Persistent postoperative pain is common after …

Importance Prolonged opioid use after surgery may be associated with opioid dependency
and increased health care use. However, published studies have reported varying estimates …