Natural product compounds have recently attracted significant attention from the scientific
community for their potent effects against inflammation-driven diseases, including cancer. A …

Cooling can reduce primary injury and prevent secondary injury to the brain after insults in
certain clinical settings and in animal models of brain insult. The mechanisms that underlie …

Neuroinflammation is a key element in the ischemic cascade after cerebral ischemia that
results in cell damage and death in the subacute phase. However, anti-inflammatory drugs …

Acute post-asphyxial encephalopathy occurring around the time of birth remains a major
cause of death and disability. The recent seminal insight that allows active neuroprotective …

Therapeutic hypothermia, or cooling of the body or brain for the purposes of preserving
organ viability, is one of the most robust neuroprotectants at both the preclinical and clinical …

Ischaemic stroke is one of the leading causes of death and disability worldwide, and
intravenous alteplase is the only proven effective treatment in the acute setting. Hypothermia …

Lithium has been used clinically to treat bipolar disorder for over half a century, and remains
a fundamental pharmacological therapy for patients with this illness. Although lithium's …

Stroke is one of the leading causes of death and disability worldwide. Current treatment
strategies for ischemic stroke primarily focus on reducing the size of ischemic damage and …

There is now compelling clinical evidence from meta-analyses of large randomized
controlled trials that in term infants with moderate to severe hypoxia-ischemia (HI) …

The aim of this article was to review current evidence about cryotherapy in inflammatory
rheumatic diseases (therapeutic and biological effects). For therapeutic effects, we …