GAD antibodies in neurological disorders—insights and challenges

F Graus, A Saiz, J Dalmau - Nature Reviews Neurology, 2020 - nature.com
Antibodies to glutamic acid decarboxylase (GAD) have been associated with several
neurological syndromes, including stiff-person syndrome, cerebellar ataxia and epilepsy …

The regulation of glutamic acid decarboxylases in GABA neurotransmission in the brain

SE Lee, Y Lee, GH Lee - Archives of pharmacal research, 2019 - Springer
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter that is required for
the control of synaptic excitation/inhibition and neural oscillation. GABA is synthesized by …

[HTML][HTML] Stiff-person syndrome and GAD antibody-spectrum disorders: GABAergic neuronal excitability, immunopathogenesis and update on antibody therapies

MC Dalakas - Neurotherapeutics, 2022 - Elsevier
Abstract Although antibodies against Glutamic Acid Decarboxylase (GAD) were originally
associated with Stiff Person Syndrome (SPS), they now denote the “GAD antibody-spectrum …

[HTML][HTML] Neuroimaging studies of GABA in schizophrenia: a systematic review with meta-analysis

A Egerton, G Modinos, D Ferrera, P McGuire - Translational psychiatry, 2017 - nature.com
Data from animal models and from postmortem studies suggest that schizophrenia is
associated with brain GABAergic dysfunction. The extent to which this is reflected in data …

Cortical deficits of glutamic acid decarboxylase 67 expression in schizophrenia: clinical, protein, and cell type-specific features

AA Curley, D Arion, DW Volk… - American Journal of …, 2011 - Am Psychiatric Assoc
Objective: Cognitive deficits in schizophrenia are associated with altered activity of the
dorsolateral prefrontal cortex, which has been attributed to lower expression of the 67 kDa …

GAD antibody-spectrum disorders: progress in clinical phenotypes, immunopathogenesis and therapeutic interventions

P Tsiortou, H Alexopoulos… - Therapeutic advances in …, 2021 - journals.sagepub.com
Antibodies against glutamic acid decarboxylase (GAD), originally linked to stiff person
syndrome (SPS), now denote the “GAD antibody-spectrum disorders”(GAD-SD) that also …

Epigenetic suppression of GAD65 expression mediates persistent pain

Z Zhang, YQ Cai, F Zou, B Bie, ZZ Pan - Nature medicine, 2011 - nature.com
Chronic pain is a common neurological disease involving lasting, multifaceted
maladaptations ranging from gene modulation to synaptic dysfunction and emotional …

The role of the GABAergic system in diseases of the central nervous system

W Zhang, BR Xiong, LQ Zhang, X Huang, X Yuan… - Neuroscience, 2021 - Elsevier
It is well known that the central nervous system (CNS) is a complex neuronal network and its
function depends on the balance between excitatory and inhibitory neurons. Disruption of …

[HTML][HTML] GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia

M Xu, AHC Wong - Acta Pharmacologica Sinica, 2018 - nature.com
Schizophrenia is considered primarily as a cognitive disorder. However, functional
outcomes in schizophrenia are limited by the lack of effective pharmacological and …

Maternal immune activation induces GAD1 and GAD2 promoter remodeling in the offspring prefrontal cortex

MA Labouesse, E Dong, DR Grayson, A Guidotti… - Epigenetics, 2015 - Taylor & Francis
Maternal infection during pregnancy increases the risk of neurodevelopmental disorders in
the offspring. In addition to its influence on other neuronal systems, this early-life …